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首页> 外文期刊>RMZ/Materials and Geoenvironment >A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children: Study design and status report
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A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children: Study design and status report

机译：围产期接触甲基汞和环境持久性有机污染物对日本儿童神经行为发育影响的队列研究：研究设计和现状报告

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Adverse effects of perinatal exposures to methylmercury (MeHg) and environmentally persistent organic pollutants (POPs) have been apparent from several birth cohort studies, but little is known about the hazardous effects in Japanese, whose fish consumption is high. The present study was designed to examine the effects of perinatal exposures to MeHg, polychlorinated biphenyls (PCB), dioxins, pesticides, and other chemicals in Japanese children. Six hundred eighty-seven pregnant women were participated in this study with their written informed consent. Maternal peripheral blood, cord blood, cord tissue, placenta, and breast milk samples were collected for chemical analysis. Maternal hair was also taken for MeHg analysis. Infants born at full term were assessed by a battery of neurobehavioral tests. The children will be continuously followed up to ages 6-7. The results of this cohort study will allow us to evaluate associations between the neurobehavioral development of children and perinatal exposures to MeHg and environmentally POPs in Japan.
机译：在几项出生队列研究中，围产期暴露于甲基汞（MeHg）和环境持久性有机污染物（POPs）的不良影响已经很明显，但对日本人的危害性知之甚少，日本人的鱼类消费量很高。本研究旨在检查围产期暴露于MeHg，多氯联苯（PCB），二恶英，农药和其他化学物质对日本儿童的影响。 67名孕妇在获得知情同意书的情况下参加了本研究。收集孕妇外周血，脐带血，脐带组织，胎盘和母乳样品进行化学分析。还采集了母发进行MeHg分析。通过一系列神经行为测试评估足月出生的婴儿。孩子们将不断接受随访，直到6-7岁。这项队列研究的结果将使我们能够评估儿童的神经行为发育与围产期暴露于MeHg和日本环境中的POPs的关系。

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