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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Associations between Infant Birth Weight and Seasonal Variations in PM2.5 Exposure during Pregnancy: A Prospective Cohort Study in a Rural Community in China
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Associations between Infant Birth Weight and Seasonal Variations in PM2.5 Exposure during Pregnancy: A Prospective Cohort Study in a Rural Community in China

机译：婴儿出生体重与孕期PM2.5暴露季节性变化之间的关联：中国农村社区的一项前瞻性队列研究

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Background: Exposure to PM2.5 (fine particulate matter) pollutants in pregnancy has generally been found to be associated with infant low birthweight. In rural China, exposure of pregnant women to PM2.5 from indoor coal or wood-burning heaters, stoves and second-hand smoke is expected to have seasonal variations that may have implications on the birth weight of the offspring. Methods: In a prospective pregnant woman cohort study, 380 pregnant women carried a Portable Particle Monitor to measure 24-hour individual exposure to PM2.5 over a period of 5-7 days at first (Tl), second (T2) and third trimester (T3) time points. The questionnaires to women were conducted simultaneously. Newborn were weighted by standard scale at birth. Latent Variable Growth Curve Modeling was used to elucidate the effects of seasonal variation to PM2.5 exposure in the course of pregnancy on the birth weight. Four groups were compared based on the season when the mother was in first trimester. Results: The average PM2.5 exposure throughout pregnancy were 27.2, 26.3, 28.3, and 30.9 u.g/m3 in four groups (their first trimester in Spring, Summer, Autumn and Winter), respectively. Different groups revealed special associational patterns. Intercept factors were -25.8, -51.3, -27.0, and -43.1 for mothers in first semester in Spring, Summer, Autumn and Winter respectively and slope factors were 0.8, -3.7, 8.4, and 8.2, respectively. Mothers in first trimester in Summer had newborns with the lowest birth weight with an increase of one unit of PM2.5 exposure being associated with a decrease in 51.3g in birth weight. Conclusions: PM2.5 exposure was associated with low birth weight across all 4 groups. Mothers who were not exposed to winter had newborns with the highest birth weights. Increased exposure to PM2.5 in the cold seasons may cause the decrease of birth weight and was associated with low birth weight.
机译：背景：妊娠中PM2.5（细颗粒物质）污染物的接触通常已被发现与婴儿低出生体重有关。在中国农村，孕妇暴露于来自室内煤炭或木材燃烧加热器，炉灶和二手烟雾的PM2.5，预计将具有对后代出生体重的季节性变化。方法：在一名前瞻性孕妇队列研究中，380名孕妇携带便携式粒子监测仪，以在第一个（TL），第二（T2）和第三个三个月的5-7天内，在5-7天内测量24小时个体暴露于PM2.5 （t3）时间点。向妇女调查问卷同时进行。新生儿在出生时被标准规模加权。潜在的可变生长曲线建模用于阐明季节性变化对妊娠期妊娠期PM2.5暴露的影响。比较四组基于母亲在孕中期的季节进行比较。结果：四组（春季，夏季，秋季和冬季）分别为27.2，26.3,28.3和30.9 u.g / m3分别为27.2,26.3,28.3和30.9 u.g / m3。不同的团体揭示了特殊的关联模式。截止因子是-25.8，-51.3，-27.0和-43.1为春季，春季，夏季，秋季和冬季分别为0.8，-3.7,8.4和8.2分别为0.8，-3.7,8.4和8.2。母亲在夏季的孕苗中患有最低出生体重的新生儿，其中一个单位的PM2.5暴露在出生体重中的51.3g下降相关。结论：PM2.5暴露于所有4组的出生体重有关。没有暴露于冬天的母亲患有最高出生体重的新生儿。在寒冷的季节中提高暴露于PM2.5可能导致出生体重降低，并且与出生体重低相关。

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