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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Herbal Medicine Containing Aristolochic Acid and the Risk of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection: A Nationwide Population-Based Cohort Study in Taiwan
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Herbal Medicine Containing Aristolochic Acid and the Risk of Hepatocellular Carcinoma in Patients with Hepatitis C Virus Infection: A Nationwide Population-Based Cohort Study in Taiwan

机译：含有马兜铃酸的草药和丙型肝炎病毒感染患者肝细胞癌的风险：台湾全国性人群研究

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Background: The purpose of this study was to investigate the association between the use of herbal medicine containing aristolochic acid (AA) and the risk of hepatocellular carcinoma (HCC) among hepatitis C virus (HCV)-infected patients. Methods and Findings: We conducted a nationwide population-based cohort study on patients older than 18 years who had a diagnosis of HCV infection between January $11997 and December 3$12010. A total of 223,467 HCV-infected patients were identified by using the National Health Insurance Research Database in Taiwan. The use of herbal medicine containing AA was identified between 1997 and 2003 and had visited traditional Chinese medicine clinics before one year before the diagnosis of HCC or the censor dates. Each patient was individually tracked from 1997 to 2013 to identify incident cases of HCC since 1999. There were 25,502 HCCs during the follow-up period of 3,052,132 person-years and the overall incidence rate was 835.5 HCCs per 100,000 person-years. The adjusted hazard ratios (HRs) were 1.21 (95% confidence interval [CI], 1.18 to 1.24), 1.48 (95% CI, 1.37 to 1.59), 1.50 (95% CI, 1.34 to 1.68), and 1.88 (95% CI, 1.61 to 2.19) for estimated AA of 1 to 250, 251 to 500, 501 to 1,000, and more than 1,000 mg, respectively, relative to no AA exposure. Conclusions: Our study suggests that AA exposure in association with HCV plays an important role in the carcinogenesis of HCC.
机译：背景：这项研究的目的是调查感染丙型肝炎病毒（HCV）的患者中使用含马兜铃酸（AA）的草药与肝细胞癌（HCC）的风险之间的关系。方法和调查结果：我们对18岁以上的被诊断为HCV感染的18岁以上患者进行了全国性队列研究，该研究在11997年1月至12010年12月3日之间进行。通过台湾国家健康保险研究数据库，总共鉴定出223,467例HCV感染患者。在1997年至2003年之间发现了使用含AA的草药的方法，并在诊断HCC或检查日期之前一年就去过中医诊所。从1997年至2013年对每个患者进行了单独跟踪，以识别自1999年以来发生的HCC病例。在3,052,132人年的随访期间，共有25,502例HCC，总发病率为每100,000人年835.5例HCC。调整后的危险比（HRs）为1.21（95％置信区间[CI]，1.18至1.24），1.48（95％CI，1.37至1.59），1.50（95％CI，1.34至1.68）和1.88（95％）相对于无AA暴露，估计AA为1至250、251至500、501至1,000和超过1,000 mg的CI（1.61至2.19）。结论：我们的研究表明，AA暴露与HCV相关在HCC的致癌作用中起着重要作用。

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