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BIOMARKERS ASSOCIATED WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS B VIRUS INFECTION, AND METHOD FOR DETECTION THEREOF
BIOMARKERS ASSOCIATED WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS B VIRUS INFECTION, AND METHOD FOR DETECTION THEREOF
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机译：乙型肝炎病毒感染患者肝细胞癌发展相关的生物标志物及其检测方法
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摘要
The present invention is intended to provide a method for predicting risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected patients with a high accuracy. More specifically, the invention provides a method for detecting eight mutations of HBV genome associated with predisposition to HCC, comprising: C1653T, A1762T, G1764A, T1674C, T1753C, C3116T, T53C and A1846T mutations, and primers and probes sets used thereof consist of SEQ ID NO: 1-SEQ ID NO: 24.
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机译：本发明旨在提供一种用于高精度预测乙型肝炎病毒（HBV）感染患者中肝细胞癌（HCC）风险的方法。更具体地，本发明提供了一种检测与易患HCC有关的HBV基因组的八个突变的方法，其包括：C1653T，A1762T，G1764A，T1674C，T1753C，C3116T，T53C和A1846T突变，以及其使用的引物和探针组由SEQ组成ID NO：1-SEQ ID NO：24。
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