• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Gene-Environmental Interaction between Cyplal, Cyplbl, and Cyp2b6 Polymorphisms and Vitamin D on Insulin Resistance: A Panel Study of an Elderly Population
【24h】

Gene-Environmental Interaction between Cyplal, Cyplbl, and Cyp2b6 Polymorphisms and Vitamin D on Insulin Resistance: A Panel Study of an Elderly Population

机译：Cyplal，Cyplbl和Cyp2b6多态性与维生素D对胰岛素抵抗的基因-环境相互作用：一个老年人群的面板研究

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: As evidence on effect of vitamin D deficiency over insulin resistance(IR) or diabetes mellitus is accumulating, investigation for any gene-environmental contribution to disease development should be accompanied. We thus evaluated the influence of certain cytochrome P450 polymorphisms and vitamin D levels on IR. Methods: Glucose, insulin as well as 25-hydroxyvitamin D levels [25(OH)D] levels from serum, and CYP1A1, CYP1B1, CYP2B6 single-nucleotide polymorphisms (SNPs) from lymphocyte DNA were measure in 535 Seoul residents over 60 years old. Homeostasis model assessment for insulin resistance(HOMA-IR) was calculated, and repeated measure analyses were used to determine the statistical association. Results: Relationship between 25(OH)D insulin (3 = -0.84, P = 0.02) or HOMA-IR (3 = -0.26, P = 0.04) was inversely significant, and influence of CYP1A1 (rsl048943), CYP1B1 (rsl62561, rs2551188) and CYP2B6 (rs3745274) SNPs on IR was found across different genotypes. Estimated effect of 25(OH)D levels on IR in the group with higher risky genotype scores of selected SNPs was greater than the group with lower genotype score. Interaction effect between vitamin D levels and genotype variations was also observed (P-interaction <.05 for both insulin and HOMA-IR). Conclusion: Genetic variations in CYP1A1, CYP1B1 and CYP2B6 and the serum levels of 25(OH)D showed interactive effect on IR.
机译：目的：作为维生素D缺乏对胰岛素抵抗（IR）或糖尿病的影响的证据正在不断积累，应对任何基因环境对疾病发展的贡献进行调查。因此，我们评估了某些细胞色素P450多态性和维生素D水平对IR的影响。方法：对535名60岁以上汉城居民的血清中的葡萄糖，胰岛素以及血清中的25-羟基维生素D水平[25（OH）D]水平以及淋巴细胞DNA的CYP1A1，CYP1B1，CYP2B6单核苷酸多态性（SNP）进行了测量。 。计算了胰岛素抵抗的稳态模型评估（HOMA-IR），并通过重复测量分析来确定统计关联。结果：25（OH）D胰岛素（3 = -0.84，P = 0.02）或HOMA-IR（3 = -0.26，P = 0.04）之间的关系呈负相关，并且CYP1A1（rs1069433），CYP1B1（rsl62561， rs2551188）和CYP2B6（rs3745274）IR上的SNP位于不同基因型之间。所选SNP的危险基因型评分较高的组中25（OH）D水平对IR的估计影响大于基因型评分较低的组。还观察到维生素D水平和基因型变异之间的相互作用作用（胰岛素和HOMA-IR的P相互作用均<.05）。结论：CYP1A1，CYP1B1和CYP2B6的遗传变异与血清25（OH）D水平对IR具有交互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号