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首页> 外文学位 >Effects of vitamin D genes on measures of insulin secretion, insulin sensitivity and adiposity: An ancillary study to the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.
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Effects of vitamin D genes on measures of insulin secretion, insulin sensitivity and adiposity: An ancillary study to the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.

机译：维生素D基因对胰岛素分泌，胰岛素敏感性和肥胖程度的影响：胰岛素抵抗动脉粥样硬化研究（IRAS）家庭研究的一项辅助研究。

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摘要

Vitamin D is associated with type 2 diabetes (T2D) quantitative traits. Three genes, the vitamin D receptor (VDR), the vitamin D binding protein (DBP), and the vitamin D 1alpha-hydroxylase (CYP27B1) have been implicated in insulin secretion, insulin sensitivity and obesity. Physical activity also plays an important role in T2D quantitative traits. The goal of this work was to determine the association between these vitamin D related genes in interaction with each other and, separately, physical activity and T2D quantitative traits. Thirty single nucleotide polymorphisms (SNPs) in these 3 genes were genotyped in 604 African Americans (42 families) from Los Angeles, 715 Hispanics (30 families) from the San Luis Valley, CO, and 710 Hispanics (60 families) from San Antonio, TX, recruited in the Insulin Resistance Atherosclerosis (IRAS) Family Study. Using the family based association test (FBAT) and the quantitative pedigree disequilibrium test (QPDT), this work investigated the association of the SNPs with acute insulin response to glucose (AIRG ) and the insulin sensitivity index (SI), calculated from a frequently-sampled intravenous glucose tolerance test; waist-to-hip ratio (WHR); abdominal visceral-to-subcutaneous fat ratio (VSR), measured by computed tomography; and the metabolic syndrome. SNPs associated with these traits by both QPDT and FBAT were examined in a generalized estimating equations model to test for gene-gene and gene-physical activity interactions. Several individual polymorphisms were associated with these traits in at least one population. There was evidence for an interaction between DBP2 and VDR1 in LA African Americans and SLV Hispanics (P=0.007 and 0.05, respectively) and between DBP2 and VDR9 in SLV Hispanics (P0.0001). There was evidence for an interaction between DBP8 and VDR6 in SLV and SA Hispanics (P=0.0008 and 0.0002, respectively) for WHR and between DBP1 and VDR13 in SLV Hispanics (P=0.0005) for WHR. There was also evidence for an interaction between DBP8 and quartiles of estimated energy expenditure in LA African Americans (P=0.0003) for VSR and between DBP7 and quartiles of estimated energy expenditure in LA African Americans (P0.0001) for SI. In summary, interactions between the DBP and VDR genes and between the DBP gene and physical activity play an important role in these traits.
机译：维生素D与2型糖尿病（T2D）定量特征有关。维生素D受体（VDR），维生素D结合蛋白（DBP）和维生素D1α-羟化酶（CYP27B1）这三个基因与胰岛素分泌，胰岛素敏感性和肥胖有关。体育活动在T2D定量特征中也起着重要作用。这项工作的目的是确定这些与维生素D相关的基因彼此之间的相互作用以及体育活动和T2D定量性状之间的关联。这3个基因的30个单核苷酸多态性（SNP）在洛杉矶的604名非洲裔美国人（42个家庭），科罗拉多州圣路易斯谷的715名西班牙裔（30个家庭）和圣安东尼奥市的710名西班牙裔（60个家庭）进行了基因分型， TX，在胰岛素抵抗性动脉粥样硬化（IRAS）家庭研究中招募。使用基于家庭的关联测试（FBAT）和定量谱系不平衡测试（QPDT），这项工作研究了SNP与急性胰岛素对葡萄糖反应（AIRG）和胰岛素敏感性指数（SI）的关联，这些关联是根据经常采样静脉葡萄糖耐量试验；腰臀比（WHR）;腹部内脏与皮下脂肪比（VSR），通过计算机体层摄影术测量；和代谢综合征。通过QPDT和FBAT与这些性状相关的SNP在广义估计方程模型中进行了检验，以测试基因-基因和基因-物理活性的相互作用。在至少一个群体中，几种个体多态性与这些性状相关。有证据表明在拉丁美洲裔美国人和SLV西班牙裔美国人中DBP2和VDR1之间存在相互作用（分别为P = 0.007和0.05），在SLV西班牙裔美国人中DBP2和VDR9之间存在相互作用（P <0.0001）。有证据表明，对于WHR，SLV和SA西班牙裔美国人中的DBP8和VDR6之间存在相互作用（分别为P = 0.0008和0.0002），对于WHR，SLV西班牙裔美国人中的DBP1和VDR13之间存在相互作用（P = 0.0005）。也有证据表明，对于VSR，DBP8与拉美非裔美国人估计的能源消耗的四分位数之间存在交互作用（P = 0.0003），对于SI而言，介于拉美非裔美国人中的DBP7和估计的四分位数之间相互影响（P <0.0001）。总之，DBP和VDR基因之间的相互作用以及DBP基因和身体活动之间的相互作用在这些性状中起重要作用。

著录项

  • 作者

    Engelman, Corinne Denise.;

  • 作者单位

    University of Colorado Health Sciences Center.;

  • 授予单位 University of Colorado Health Sciences Center.;
  • 学科 Biology Genetics.;Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 203 p.
  • 总页数 203
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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