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首页> 外文期刊>Diabetes care >Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study.
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Dietary glycemic index and glycemic load, carbohydrate and fiber intake, and measures of insulin sensitivity, secretion, and adiposity in the Insulin Resistance Atherosclerosis Study.

机译：胰岛素抵抗性动脉粥样硬化研究中的饮食血糖指数和血糖负荷，碳水化合物和纤维摄入量以及胰岛素敏感性，分泌和肥胖的测量。

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OBJECTIVE: We studied the association of digestible carbohydrates, fiber intake, glycemic index, and glycemic load with insulin sensitivity (S(I)), fasting insulin, acute insulin response (AIR), disposition index, BMI, and waist circumference. RESEARCH DESIGN AND METHODS: Data on 979 adults with normal (67%) and impaired (33%) glucose tolerance from the Insulin Resistance Atherosclerosis Study (1992-1994) were analyzed. Usual dietary intake was assessed via a 114-item interviewer-administered food frequency questionnaire from which nutrient intakes were estimated. Published glycemic index values were assigned to food items and average dietary glycemic index and glycemic load calculated per subject. S(I) and AIR were determined by frequently sampled intravenous glucose tolerance test. Disposition index was calculated by multiplying S(I) with AIR. Multiple linear regression modeling was employed. RESULTS: No association was observed between glycemic index and S(I), fasting insulin, AIR, disposition index, BMI, or waist circumference after adjustment for demographic characteristics or family history of diabetes, energy expenditure, and smoking. Associations observed for digestible carbohydrates and glycemic load, respectively, with S(I), insulin secretion, and adiposity (adjusted for demographics and main confounders) were entirely explained by energy intake. In contrast, fiber was associated positively with S(I) and disposition index and inversely with fasting insulin, BMI, and waist circumference but not with AIR. CONCLUSION: Carbohydrates as reflected in glycemic index and glycemic load may not be related to measures of insulin sensitivity, insulin secretion, and adiposity. Fiber intake may not only have beneficial effects on insulin sensitivity and adiposity, but also on pancreatic functionality.
机译：目的：我们研究了可消化碳水化合物，纤维摄入量，血糖指数和血糖负荷与胰岛素敏感性（S（I）），空腹胰岛素，急性胰岛素反应（AIR），处置指数，BMI和腰围的关系。研究设计与方法：分析了胰岛素抵抗性动脉粥样硬化研究（1992-1994）中979名正常（67％）和糖耐量受损（33％）的成年人的数据。日常饮食摄入量是通过由114名访调员管理的食物频率问卷评估的，据此估算了营养摄入量。将发布的血糖指数值分配给食品，并按每个受试者计算平均饮食血糖指数和血糖负荷。 S（I）和AIR通过频繁采样的静脉葡萄糖耐量试验确定。通过将S（I）与AIR相乘来计算处置指数。采用多元线性回归建模。结果：在调整了人口统计学特征或糖尿病家族史，能量消耗和吸烟后，未发现血糖指数与S（I），空腹胰岛素，AIR，性倾向指数，BMI或腰围之间存在关联。能量摄入完全可以解释观察到的可消化碳水化合物和血糖负荷与S（I），胰岛素分泌和肥胖的关系（根据人口统计学和主要混杂因素进行调整）。相比之下，纤维与S（I）和性状指数呈正相关，与空腹胰岛素，BMI和腰围呈负相关，而与AIR不相关。结论：血糖指数和血糖负荷所反映的碳水化合物可能与胰岛素敏感性，胰岛素分泌和肥胖症的测定无关。纤维摄入可能不仅对胰岛素敏感性和肥胖有有益作用，而且对胰腺功能也有影响。

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