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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Chronic PM2.5 Exposure and Lipids/Lipoproteins among Midlife Women
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Chronic PM2.5 Exposure and Lipids/Lipoproteins among Midlife Women

机译：中年妇女的慢性PM2.5暴露和脂质/脂蛋白

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Fine particles (PM2.5) are known to increase risks of cardiovascular diseases, but very few studies have examined impact of long-term PM2.5 exposure on plasma lipid. In this study, we examined the association between PM2.5 exposure and lipid/lipoprotein among 2289 midlife women from six sites across U.S. between 1999 and 2005 (average 49±3 years old at the first visit included), and explored potential vulnerable subgroups. PM2.5 data were obtained from the U.S. Environmental Protection Agency monitoring network. The average prior one-year exposure was calculated and assigned to each woman based on proximity of the monitors to her residential address. Mixed effects models were used to account for repeated measures for each woman, adjusted for site, race/ethnicity, education, and time-varying variables including age at the visit, visit number, menopausal status, body mass index (BMI), smoking status, alcohol use in the past 24 hours, hormone use, and non-work activity level. The changes in lipids/lipoproteins presented different patterns by dyslipidemia status, menopausal status, and BMI categories. With increased PM2.5 exposure, increased atherogenic lipoproteins, such as, Apolipoprotein (Apo) B and lipoprotein(a), were observed in women without dyslipidemia and women with BMI less than 25, e.g., 5.0% (95%th CIs: 0.8%, 9.4%) and 6.1% (1.1%, 11.3%) increases in ApoB in these two groups, respectively, per 10 μg/m3 increase of one-year average PM2.5 exposure. Reduced protective lipoproteins, including ApoA1 and lipoprotein A1, were observed in women with dyslipidemia and overweight (2530) women. Both trends were observed in peri-menopausal women (had a period within the past 11 months but became irregular). These results suggested that chronic PM2.5 exposure was adversely associated with lipid levels through different mechanisms in midlife women, and all lead to increased cardiovascular risks.
机译：众所周知，细颗粒物（PM2.5）会增加患心血管疾病的风险，但是很少有研究检查长期暴露于PM2.5对血脂的影响。在这项研究中，我们研究了1999年至2005年期间，来自美国六个地点的2289名中年妇女中PM2.5暴露与脂质/脂蛋白之间的关联（包括首次访问时平均49±3岁），并探讨了潜在的弱势亚组。 PM2.5数据是从美国环境保护署的监控网络获得的。计算前一年的平均暴露量，并根据监控器与其住所地址的接近程度将其分配给每位女性。使用混合效应模型对每个女性进行重复测量，并针对部位，种族/民族，教育程度和时变变量进行调整，包括就诊年龄，就诊次数，绝经状态，体重指数（BMI），吸烟状态，过去24小时内的酒精使用量，激素使用量和非工作活动水平。血脂异常状态，更年期状态和BMI类别显示脂质/脂蛋白的变化呈现出不同的模式。随着PM2.5暴露量的增加，在没有血脂异常的妇女和BMI低于25的妇女中观察到动脉粥样硬化的脂蛋白（如载脂蛋白（Apo）B和脂蛋白（a））增加，例如5.0％（95％的CI：0.8）每增加10μg/ m3，一年平均PM2.5暴露量的增加，两组的ApoB分别增加％，9.4％）和6.1％（1.1％，11.3％）。在血脂异常和超重（25 30）妇女中，观察到保护性脂蛋白（包括ApoA1和脂蛋白A1）减少。在绝经期妇女中都观察到了这两种趋势（过去11个月有一段时间，但后来变得不规律）。这些结果表明，通过中年妇女的不同机制，长期暴露于PM2.5与血脂水平呈负相关，并且所有这些都会导致心血管疾病的风险增加。

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