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Accurate Technique for Measuring Electrical Permittivity of Biological Tissues at Low Frequencies and Sensitivity Analysis

机译:低频下生物组织介电常数的精确测量技术及灵敏度分析

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This paper presents an accurate technique for measuring electrical permittivity (EP) of small biological tissue specimens at low frequencies while measurement sensitivity to specimen geometry and tissue specimen inhomogeneity is investigated. Accurate EP measurement of various biological tissues, including healthy and pathological tissues, can pave the way for a wide range of medical applications. This novel technique utilizes a high precision hardware for impedance measurement of a capacitive structure formed by two conductive plates and the tissue specimen as its dielectric. The capacitance part of the measured impedance is processed using an inverse finite element framework to determine the tissue electrical permittivity. This framework considers specimen's accurate geometry and boundary conditions. After successful validation, the technique was employed to measure electrical permittivity of several specimens of bovine heart, liver and bone tissues. The proposed technique is reliable and is expected to offer improved measurement accuracy and repeatability of electrical permittivity of multi-layered tissue specimens, especially at low frequencies.
机译:本文提出了一种精确的技术,用于在低频下测量小型生物组织标本的介电常数(EP),同时研究了对标本几何形状和组织标本不均匀性的测量灵敏度。对包括健康和病理组织在内的各种生物组织进行准确的EP测量,可以为广泛的医学应用铺平道路。这项新颖的技术利用高精度硬件对由两个导电板和组织样本作为其电介质形成的电容结构进行阻抗测量。使用逆有限元框架处理所测量阻抗的电容部分,以确定组织的介电常数。该框架考虑了标本的精确几何形状和边界条件。成功验证后,该技术用于测量牛心脏,肝脏和骨骼组织的多个标本的介电常数。所提出的技术是可靠的,并且有望提供改进的测量精度和多层组织样本的介电常数的可重复性,尤其是在低频下。

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