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Biomechanics of the Vertebral Column and Internal Organ Response to Seated Spinal Impact in the Rhesus Monkey (Macaca Mulatta)

机译:椎体柱的生物力学和内部器官对岩石猴(Macaca Mulatta)坐着的脊柱冲击的反应

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Rhesus monkeys were anesthetized; radiographed; restrained by lap belt, torso harness, and limb retention straps; positioned in an impact carriage; and exposed to + G z seated rectangular acceleration-time histories from predetermined drop heights. The shock programmer used throughout these experiments was aluminum honeycomb. Pulse accelerations ranged 25-900 G and total time duration 2-22 ms. Shortly after impact, all primates were radiographed, killed, and a necropsy performed. Attempts were made to determine injury potential as a function of plateau acceleration and pulse duration for various target organs. Spinal injury data support previous results and theoretical considerations that there are two distinct injury potential regimes; one, for which the velocity change is the determining physical parameter, and the other for which peak g is the determining factor. Injuries observed in parenchymatous organs included external and surface hemorrhaging in the liver, lesions of the lung, and cardiac lesions. Their severity ranged from minor reversible abrasions to lethal trauma. These experiments strengthened confidence in the applicability of animal experiments to the quantitative explanation of human injury and to the extrapolation of animal results - after the application of the proper scaling factors - to human situations.
机译:恒河猴被麻醉了;射线照相;由圈带,躯干线束和肢体保留带束缚;定位在冲击马车;从预定的下降高度暴露于+ G Z Z Z型矩形加速时间历史。在这些实验中使用的休克编程器是铝蜂窝状。脉冲加速度范围为25-900克和总时间持续时间2-22毫秒。撞击后不久,所有灵长类动物均被射线照相,杀死和尸检进行。尝试确定各种靶器官的平台加速和脉冲持续时间的损伤潜力。脊柱损伤数据支持以前的结果和有两个不同伤害潜在制度的理论考虑因素;一个,速度变化是确定物理参数,并且峰值G是确定因子的另一个。在盲对动力器中观察到的损伤包括肝脏,肺病变和心脏病变的外部和表面出血。他们的严重程度从轻微的可逆擦伤到致命的创伤。这些实验强化了动物实验适用于人体损伤的定量解释和动物结果的外推 - 在适当的缩放因子 - 对人类情况下的应用中的应用。

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