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首页> 外文会议>IEEE Engineering in Medicine and Biology Annual Conference >Adsorbed endotoxin mediates differential effects on particle-induced stimulation of cytokine and chemokine release
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Adsorbed endotoxin mediates differential effects on particle-induced stimulation of cytokine and chemokine release

机译：吸附的内毒素介导对细胞因子和趋化因子释放的颗粒诱导的刺激差异影响

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Studies have demonstrated the capacity of metal wear particles from orthopaedic implants to stimulate the release of a variety of pro-inflammatory products. Little is known, however, concerning the mechanisms by which particle attachment andinternalization lead to cell activation. Among the factors that influence reactivity are the intrinsic physical chemical properties of the particulate species but also the capacity of the particles to bind serum factors and to present them to cells. Thecell responses are then transduced via interactions between these factors (opsonins) and specific cell surface receptors. Ragab et al [1] have recently reported that adsorbed bacterial endotoxin is the major factor responsible for activation of cells bytitanium metal particles. In the present studies we confirm these observations and further investigate the differential capacity of particles to bind endotoxin and induce distinct patterns of cytokine and chemokine responses.
机译：研究表明，矫形植入物中金属磨损颗粒的能力刺激各种促炎产物的释放。然而，关于颗粒连接和氮气化导致细胞活化的机制很少。影响反应性的因素是颗粒物种的内在物理化学性质，而且还具有颗粒结合血清因子的能力并将它们呈现给细胞。然后通过这些因素（Opsonins）和特定细胞表面受体之间的相互作用来转导响应。 Ragab等人[1]最近报道了吸附的细菌内毒素是负责激活细胞硝基金属颗粒的主要因素。在本研究中，我们确认了这些观察结果，并进一步研究了颗粒与结合内毒素的差异容量，并诱导细胞因子和趋化因子反应的不同模式。

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