Safety of a new Actinobacillus pleuropneumoniae sub-unit vaccine in laboratory studies and field trial

机译：新的Actinobacillus胸膜内血管内疫苗在实验室研究和田间试验中的安全性

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A new Actinobacillus pleuropneumoniae sub-unit vaccine has been developed. Whole-cell App vaccines are known for possible poor safety. The development of this new vaccine was optimised to obtain a good safety and efficacy. The safety of the administration of one dose and an overdose of the vaccine was thoroughly evaluated in the target species in conventional and susceptible (SPF) pigs under laboratory conditions. A safety field trial was also conducted on three different farms. The vaccine containsthe inactivated, purified Apx antigens (Apxl, ApxII and ApxIUXI). The vaccine is also adjuvanted with aluminium hydroxide gel. It is administered by the IM route (2ml per animal) and two injections are given from the age of 6 weeks to protect piglets assoon as possible in and for the duration of the finishing period.

机译：开发了一种新的actinobacillus胸膜肺炎疫苗。全细胞APP疫苗众所周知，安全性差。优化了这种新疫苗的发展，以获得良好的安全性和功效。在实验室条件下，在常规和易感（SPF）猪中的靶种类中彻底评价了一种剂量和过量疫苗的给药的安全性。还在三个不同的农场进行安全现场试验。疫苗含有灭活，纯化的APX抗原（APX1，APXII和APXIUXI）。疫苗也辅助氢氧化铝凝胶。它由IM途径（每只动物2ml）给药，两次注射给药6周龄，以保护仔猪固化在整理期间和持续时间内保护仔猪。

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《Congress of the International Pig Veterinary Society》|1999年||共1页
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J. Thevenon; J. B. Herin; B. Fily; F. Teppe; A. Prats; A. Brun; F. Milward;
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1. An evaluation of the role of antibodies to Actinobacillus pleuropneumoniae serovar 1 and 15 in the protection provided by sub-unit and live streptomycin-dependent pleuropneumonia vaccines [J] . JQ TUMAMAO, RE BOWLES, H VAN DEN BOSCH, Australian Veterinary Journal . 2004,第12期

机译：评估胸膜肺炎放线杆菌血清1和15抗体在亚单位和链霉素依赖型胸膜肺炎活疫苗提供的保护中的作用
2. A Field Trial of Oil Adjuvanten Trivalent Actinobacillus pleuropneumoniae Vaccine [J] . Chieko MATSUDA, Eiji OISHI, Hisae NAKAMURA, The Journal of Veterinary Medical Science . 1997,第5期

机译：油佐剂三价胸膜肺炎放线杆菌疫苗的田间试验
3. Randomised controlled field study to evaluate the efficacy and clinical safety of a single 8?mg/kg injectable dose of marbofloxacin compared with one or two doses of 7.5?mg/kg injectable enrofloxacin for the treatment of Actinobacillus pleuropneumoniae infections in growing-fattening pigs in Europe [J] . Erik Grandemange, Pierre-Alexandre Perrin, Dejean Cvejic, Porcine health management. . 2017,第1期

机译：随机对照现场研究评估了单剂量8？mg / kg注射剂量的marbofloxacin与一或两剂7.5？mg / kg可注射的恩诺沙星治疗生长型猪胸膜肺炎放线杆菌感染的疗效和临床安全性欧洲
4. Safety of a new Actinobacillus pleuropneumoniae sub-unit vaccine in laboratory studies and field trial [C] . J. Thevenon, J. B. Herin, B. Fily, Congress of the International Pig Veterinary Society . 1999

机译：新的Actinobacillus胸膜内血管内疫苗在实验室研究和田间试验中的安全性
5. Development of conjugate vaccines to protect pigs against swine pleuropneumonia induced by Actinobacillus pleuropneumoniae. [D] . Byrd, Wyatt. 1991

机译：开发结合疫苗以保护猪免受猪胸膜肺炎放线杆菌诱导的猪胸膜肺炎。
6. Randomised controlled field study to evaluate the efficacy and clinical safety of a single 8 mg/kg injectable dose of marbofloxacin compared with one or two doses of 7.5 mg/kg injectable enrofloxacin for the treatment of Actinobacillus pleuropneumoniae infections in growing-fattening pigs in Europe [O] . Erik Grandemange, Pierre-Alexandre Perrin, Dejean Cvejic, 2017

机译：随机对照现场研究评估单次8 mg / kg注射剂量的马洛沙星与一或两次7.5 mg / kg注射性恩诺沙星对欧洲成长型猪胸膜肺炎放线杆菌感染的疗效和临床安全性
7. An evaluation of the role of antibodies to Actinobacillus pleuropneumoniae serovar 1 and 15 in the protection provided by sub-unit and live streptomycin-dependent pleuropneumonia vaccines [O] . Tumamao J.Q., Bowles R.E., van den Bosch H., 2003

机译：评估胸膜肺炎放线杆菌血清1和15抗体在亚单位和链霉素依赖型胸膜肺炎活疫苗提供的保护中的作用
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机译：秘鲁健康婴儿和儿童两种黄热病17D疫苗（aRILVaX（商标）和YF-VaX（商标））的比较免疫原性安全性和耐受性的随机双盲III期关键现场试验

Safety of a new Actinobacillus pleuropneumoniae sub-unit vaccine in laboratory studies and field trial

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