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Variability of the ethanol induced reaction in pigs

机译：乙醇诱导猪中反应的可变性

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Most pharmacogentic research has used genetic animal models to understand how drugs exert their additive effect and to predict individual susceptibility to those effects. Using pigs may give some benefits in the above studies: their similarity to humans in structure and function of organs and tissues is well-known. Genetic investigation of mice showed the existence of a strong genetic control of alcohol-related behaviour. Sensitivity 10 ethanol- induced hypothermia is also of genetic origin and maybe genetically correlated with EtOH sedation effect. EtOH metabolism may be also associated with stress-susceptibility of humans and animals. It would seem to be helpful to understand the phenotypic and genetic variation of ethanol-induced reactions inlarge mammals. The reaction of piglets of 1-month age to per-oral treatmenl with 25 percent ethanol at 2g/kg was obtained. The rectal temperature was recorded before the treatment and 60 minutes after it. 121 animals were tested. According to their reaction individuals were distributed in groups: sensitive (groups 1) - they decreased the rectal temperature to 0,1 -1,207 deg C; resistant - animals maintained the temperature (group 2) or increased it (hyperthermia, group 3).
机译：大多数药理学研究使用遗传动物模型来了解药物如何施加效果，并预测对这些效果的个人易感性。使用猪可以在上述研究中给出一些好处：它们对器官和组织的结构和功能中对人类的相似性是众所周知的。小鼠的遗传调查表明，存在与酒精相关行为的强遗传控制的存在。敏感性10乙醇诱导的低温也是遗传来源，也许与EtOH镇静效果的遗传相关。 EtoH代谢也可能与人类和动物的应力易感性相关。了解乙醇诱导的反应的表型和遗传变异似乎有助于促进哺乳动物的表型和遗传变异。获得1个月龄的仔猪在2g / kg下用25％乙醇的每口服治疗的仔猪反应。在治疗前记录直肠温度，并在其后60分钟记录。测试了121只动物。根据其反应，个体分布在组中：敏感（组1） - 它们降低了直肠温度至0.1 -1,207℃;抗性 - 动物保持温度（第2组）或增加它（高温，第3组）。

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