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Effect of dietary calcium: Phosphorus ratio on bone mineralization and intestinal calcium absorption in ovariectomized rats

机译：膳食钙的影响：卵矿化与卵巢切除大鼠骨矿化和肠钙吸收的影响

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We investigated the effect of dietary calcium:phosphorus (Ca:P) ratio on bone mineralization and intestinal Ca absorption in ovariectomized (OVX) rat models of osteoporosis and sham-operated rats. Thirty 12-wk-old female Wistar rats were divided into three groups of OVX rats and three groups of sham rats. Thirty days after the adaptation period, OVX rats and sham rats were fed a diet formulated Ca:P, 1:0.5, 1:1 or 1:2 (each diet containing 0.5% Ca), respectively for 42 d. In both sham and OVX rats, serum osteocalcin, a marker of bone turnover, was increased by decreasing Ca:P ratio (1:2). In contrast, rats fed the Ca:P = 1:0.5 diet (dietary P restriction) suppressed the increased serum parathyroid hormone, osteocalcin and urinary deoxypyridinoline, and increased Ca absorption in both sham and OVX rats compared to the Ca:P =1:1 and 1:2 diets. Especially, in OVX rats, the decreased bone mineral density of the fifth lumbar was also suppressed when rats were fed the Ca:P = 1:0.5 diet. These results indicated that the elevation of dietary Ca:P ratio may inhibit bone loss and increase intestinal Ca absorption in OVX rats.
机译：我们调查了膳食钙：磷（Ca：p）比对卵巢术（Ovx）大鼠骨质疏松症和假手术大鼠大鼠大鼠骨质矿化和肠CA吸收的影响。三十个12倍的女性Wistar大鼠分为三组OVX大鼠和三组假大鼠。适应期30天，EVX大鼠和假大鼠喂食配方CA：p，1：0.5,1：1或1：2（每次含有0.5％CA的饮食），42 d。在假和OVX大鼠中，通过降低Ca：P比率（1：2），增加了血清骨钙素，骨周转标志物。相反，喂养CA的大鼠：P = 1：0.5饮食（膳食P限制）抑制了增加的血清甲状旁腺激素，骨钙素和泌尿氧基吡啶啉，并与CA相比，Sham和OVX大鼠的增加量增加：P = 1： 1和1：2饮食。特别是，在OVX大鼠中，当大鼠加入CA时，也抑制了第五腰骨的骨密度降低：P = 1：0.5饮食。这些结果表明，膳食CA：P比率的升高可能会抑制骨质损失并增加OVX大鼠的肠道CA吸收。

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