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Upregulation of Cysteinvl-leukotriene 1 Receptor Expression by lnterleukin-5 in human leukocytes

机译:人体白细胞中Lnterukin-5的Cysteinvl-Leukotriene1受体表达的上调

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The cysteinyl-leukotrienes (cysLTs), LTC_4, LTD_4, and LTE_4 are potent lipid mediators implicated mainly in acute bronchoconstriction and chronic airway inflammation in asthma [1]. Blood eosinophils from asthmatic patients synthesize increased amounts of cys-LTs. Cys-LTs, in turn, have in vitro chemoattractant activity for human eosinophils. LTD4-induced eosinophil infiltration of the airway could be blocked by the cysLT antagonist MK-571 [2].
机译:Cysteinyl-白三烯(Cyslts),LTC_4,LTD_4和LTE_4是有效的脂质介质,主要涉及哮喘急性支气管混凝土和慢性气道炎症[1]。来自哮喘患者的血液粒细胞综合含量增加的Cys-LT。反过来,Cys-LTS对人嗜酸性粒细胞的体外化学趋化性活性。有限公司诱导嗜酸性粒细胞渗透的气道可以被Cyslt拮抗剂MK-571封锁[2]。

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