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Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones

机译：用抗原特异性T细胞克隆采用人类疾病的免疫治疗

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Cellular adoptive immunotherapy refers to the transfer of effector cells of the immune system to treat infectious or malignant diseases. Our laboratory has been investigating the use of adoptive immunotherapy with antigen-specific T-cell clones to prevent cytomegalovirus (CMV) infection in allogeneic bone marrow transplant (BMT) recipients; augment immune responses to human immunodeficiency virus (HIV) in HIV-seropositive individuals; and to induce a graft-versus-leukemia (GVL) response in allogeneic BMT recipients. In each of these settings the rationale for developing adoptive immunotherapy is based on clear evidence that deficiencies of antigen-specific T cells are responsible for disease progression. Functional studies of effector activity and genetic markers have been used to demonstrate that adoptively transferred T-cell clones can persist and function in the host and migrate appropriately to sites of disease. It is anticipated that additional studies will define disease settings in which T-cell therapy can be beneficial and further elucidate the requirements for effective immunotherapy in humans.
机译：细胞收养免疫疗法是指免疫系统的效应细胞转移治疗传染病或恶性疾病。我们的实验室一直在调查使用抗原特异性T细胞克隆的养老疗法，以防止同种异体骨髓移植（BMT）受体中的巨细胞病毒（CMV）感染;在艾滋病毒血清阳性个体中延长免疫应对人类免疫缺陷病毒（HIV）;并诱导同种异体BMT受体中的移植物与白血病（GVL）反应。在这些设置中的每一个中，开发养老免疫疗法的理由是基于明确的证据，即抗原特异性T细胞的缺陷负责疾病进展。效应活性和遗传标记的功能性研究已经过去用于证明养类转移的T细胞克隆可以在宿主中持续和起作用并适当地迁移至疾病部位。预计额外的研究将定义疾病环境，其中T细胞治疗可能是有益的，进一步阐明人类有效免疫疗法的要求。

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