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首页> 外文会议>Congress of the International Pig Veterinary Society >DETECTION OF ERYSIPELAS ANTIBODIES IN VACCINATED PIGS IN A FIELD TRIAL AND IN A CHALLENGE TEST
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DETECTION OF ERYSIPELAS ANTIBODIES IN VACCINATED PIGS IN A FIELD TRIAL AND IN A CHALLENGE TEST

机译：在野外试验和挑战试验中检测疫苗猪的酸酐抗体

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Swine erysipelas is a disease caused by the bacterium Erysipelothrix (E.) rhusiopathae. The worldwide distribution of this disease makes it economically very important. Swine erysipelas manifests itself as either an acute or subacute septicemia, oftenaccompanied by characteristic skin lesions. A chronic manifestation with arthritis and endocarditis is also very common. In a field trial, the production of antibodies, induced by a combined vaccine, directed against both the porcine parvovirus and swine erysipelas containing Serotype 2 (PARVORUVAC~(R), MERIAL GmbH, Germany), was compared with that of the corresponding monovalent vaccine (RUSILAT~(R), MERIAL GmbH, Germany). Furthermore, these vaccines were used in different vaccination (vacc.) schemes.The field trial was carried out on 109 gilts, located in three closed farms. A group of 12 gilts was housed separately for the challenge experiments. First, a basic immunization was carried out twice in all gilts at the age of six months, within a threeweek interval, according to the instructions for use. Then, a revaccination was carried out, four or six months after the basic immunisation, on 50% of the animals for each time interval (Table 1). A challenge test was carried out four weeks after eachof the revaccination, in eight vaccinated and four non-vaccinated gilts housed sperately. An mtradermal challenge with current isolates of serotypes 1 and 2 of E. rhusiopathiae was applied (1). In order to study the production of antibodies against swineerysipelas, blood samples were collected from the gilts, before the first and second vaccination, before the revaccination and four weeks after the revaccination. The titres were measured in an ELISA (2,3,4) and the results were transformed into -log10values for statistical calculations. Statistical analysis was performed using SAS System (variance analysis).
机译：Swine Erysipelas是由细菌酸酐（E.）Rhusiopathae引起的疾病。全世界的这种疾病的分布使其在经济上非常重要。猪酸辣椒体表现为急性或亚急性败血症，Museccompanied由特征性皮肤病变。具有关节炎和心内膜炎的慢性表现也很常见。在田间试验中，将由组合疫苗引起的抗体的抗体的产生，针对含有血清型2（Parvoruvac〜（R），合并GmbH，德国）的猪剖视性和猪酸乳头蛋黄酱，与相应的一价疫苗进行比较（Rusilat〜（r），德国合作Gmbh）。此外，这些疫苗用于不同的疫苗接种（VIVC。）方案。现场试验在109个吉尔茨进行，位于三个封闭的农场。为挑战实验分开容纳12个吉尔特。首先，根据使用说明，在三周间隔内，在六个月内的所有吉尔中进行两次基本免疫接种。然后，在基本免疫后4或六个月进行重新发生，每次间隔的50％的动物（表1）。每次重新发生后四周进行挑战测试，八个疫苗接种，四个非接种疫苗的吉尔特匹配。用电流分离株的血清型1和2的血清疗法的麦克拉德米尔挑战施用（1）。为了研究针对盐酸纤维素的抗体，在第一次和第二次疫苗接种前，在重新发生之前和再加工后四周，从吉尔茨收集血液样品。在ELISA（2,3,4）中测量滴度，并将结果转化为-Log10值以进行统计计算。使用SAS系统（方差分析）进行统计分析。

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