In Vitro-In Vivo Correlation of BCNU release using Gliadel~direct R Wafers with Three Drug Loadings and Two Different Thicknesses

机译：使用Gliadel〜Direct R晶片与三种药物载荷和两种不同厚度的体外相关的体内相关性

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The Gliadel~direct R wafer is a biodegradable polymer based drug delivery system developed by Guilford Pharmaceuticals, Inc. as an adjunct therapy to surgery for the treatment of glioblastoma multiformate. Wafers are implanted into the resection cavity following tumor removal and deliver high concentrations of the chemotherapeutic agent Carmustine (BCNU) directly to the site for an extended period of time. Commercially available Gliadel~direct R consist of 200 mg wafers containing 3.85 percent BCNU which are 14 mm in diameter and approximately 1 mm thick.

机译：Gliadel〜Direct R晶片是由Guilford Pharmaceuticals，Inc。开发的可生物降解的聚合物基于基于聚合物的药物递送系统，作为治疗胶质母细胞瘤的辅助治疗。在肿瘤移除后植入切除腔中的晶片并将高浓度的化学治疗剂Carmustine（BCNU）直接延长到部位。市售的Gliadel〜Direct R组成的200mg晶片含有3.85％的BCNU，直径为14毫米，厚度为1mm。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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J.Sclafani; D.Cline; W.Dang;
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中图分类生物材料学;
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4. In Vitro-In Vivo Correlation of BCNU release using Gliadel~direct R Wafers with Three Drug Loadings and Two Different Thicknesses [C] . J.Sclafani, D.Cline, W.Dang International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：具有三种药物装载量和两种不同厚度的Gliadel〜direct R晶片的BCNU释放的离体体内相关性
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In Vitro-In Vivo Correlation of BCNU release using Gliadel~direct R Wafers with Three Drug Loadings and Two Different Thicknesses

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