Poly(lactic acid-co-glycolic acid) Microsphere Formulations For DNA Vaccines: 1. Physico-chemical Characterization and Release Kinetics

机译：DNA疫苗的聚（乳酸二乙醇酸）微球制剂：1。物理化学表征和释放动力学

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The administration of plasmid DNA encoding antigenic proteins to induce humoral and cellular immune responses is emerging as an exciting immunization strategy (1). Delivery of the plasmid DNA via microparticles (<10 mu dia.) helps target the DNA to antigen presenting cells (APC), thereby initiating the induction of immune responses (2). Microspheres provide the added benefit of protecting the encapsulated DNA from enzymatic degradation in-vivo. Microspheres comprised of poly(lactic acdi-co-glycolic acdi) (PLGA) are normally used in this regard, due to their biodegradability, biocompatibility and history of safe use in humans (3).

机译：编码抗原蛋白质的质粒DNA施用以诱导体液和细胞免疫应答的促进作为激动的免疫策略（1）。通过微粒（<10μmAta）递送质粒DNA，有助于将DNA靶向抗原呈递细胞（APC），从而引发免疫应答的诱导（2）。微球提供保护从体内酶促降解的包封DNA的增加的益处。由聚（乳酸ACDI-乙二醇ACDI）（PLGA）组成的微球通常用于这方面，因为它们的生物降解性，生物相容性和人类安全使用的历史（3）。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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S.Barman; Y.Hsu; L.Lunsford; T.Hao; P.Chambers; U.Mckeever; M.L.Hedley;
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中图分类生物材料学;
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4. Poly(lactic acid-co-glycolic acid) Microsphere Formulations For DNA Vaccines: 1. Physico-chemical Characterization and Release Kinetics [C] . S.Barman, Y.Hsu, L.Lunsford, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

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Poly(lactic acid-co-glycolic acid) Microsphere Formulations For DNA Vaccines: 1. Physico-chemical Characterization and Release Kinetics

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