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Polyphosphoester paclitaxel microspheres (paclimer~TM microspheres): in vitro characterization using hplc and LC/MS

机译：聚磷酸酯紫杉醇微球（PACLIMER〜TM微球）：使用HPLC和LC / MS体外表征

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摘要

PACLIMER~TM microspheres is an injectable biodegradable polymer formulation of paclitaxel developed by Guilford Pharmaceuticals, Inc. Unlike traditional systemic chemotherapeutic regimes, PACLIMER~TM microspheres is designed to provide site-specific and controlled delivery of paclitaxel, and has been effective against various types of cancer in preclinical animal models~(1-2). In this paper, we report the preparation and in vitro characterization of paclitaxel microsphere formulation (PACLIMER~TM microspheres) using a robust reversed phase HPLC method for quantitation and further structural elucidation using LC/MS techniques. The polymer used in the microsphere formulation is a biodegradable polyphosphoester (PPE) polilactofate polymer, which has shown great promise in controlled delivery of a variety of therapeutic agents, ranging from small molecules to proteins and nucleic acids~(3-5).
机译：PACLIMER〜TM微球是由Guilford Pharmaceuticals，Inc的可注射的可脱脂可可植物的聚合物制剂。与传统的全身化学治疗制度不同，PACLIMER〜TM微球旨在提供紫杉醇的场地特异性和控制的递送，并对各种类型有效临床前动物模型的癌症〜（1-2）。在本文中，我们使用LC / MS技术使用稳健的反相HPLC方法报告紫杉醇微球体制剂（PACLIMER〜TM微球）的制备和体外表征。微球体制剂中使用的聚合物是可生物降解的多相磷酸酯（PPE）酚酸酯聚合物，其在受控递送各种治疗剂中表现出很大的希望，从小分子到蛋白质和核酸〜（3-5）。

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