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首页> 外文会议>International symposium on controlled release of bioactive materials >Self-assembling polyvinylalcohol derivatives, interactions with drugs and control of release.
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Self-assembling polyvinylalcohol derivatives, interactions with drugs and control of release.

机译：自组装聚乙烯醇衍生物，与药物的相互作用和释放的控制。

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In recent years, self-assembling polymers have been the object of growing scientific interest due to their ability to entrap poorly water soluble drugs in their inner core~1,2,3,4,5. This interaction may provide different performance of the drug-polymer system depending on the extent of the drug-polymer interaction: increased drug availability and control of drug release in the presence of weak interactions, longer residence time of the drug in the organism or drug targeting in the presence of strong interactions. This work describes the use of PVA substituted with residues able to confer amphiphilic properties on the polymer thus providing self-assembling structures allowing the entrapment of indomethacin. For this purpose we substituted PVa with 2-hydroxypropyltrimethylammonium and with acyl chains of different molecular weight: butyryl (B), capryloyl (C), lauroyl (L) or myristoyl (M) and evalauted the functional properties of these derivatives both in terms of their physico-chemical characteristics and their ability to interact with the drug and control its release.
机译：近年来，自组装聚合物是由于它们在内核中捕获不良水溶性的水溶性药物〜1,2,3,4,5而产生科学兴趣的目的。这种相互作用可以提供取决于药物 - 聚合物相互作用的程度的药物 - 聚合物系统的不同性能：增加的药物的可用性和药物释放在弱相互作用的存在的控制下，药物在生物体或靶向药物更长的停留时间在存在强烈的相互作用。该工作描述了使用能够在聚合物上赋予两亲性质的残基取代的PVA，从而提供自组装结构，允许嵌入吲哚美辛。为此目的，我们用2-羟丙基三甲基氨基取代PVA，并用不同分子量的酰基链：丁酰基（B），甲酰基（C），月桂酰基（L）或Myristoyl（M），并在方面评价这些衍生物的功能性质它们的物理化学特性及其与药物相互作用的能力并控制其释放。

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