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首页> 外文会议>International symposium on controlled release of bioactive materials >Formulation of a bioadhesive bilayered buccal tablet of natamycin for oral candidiasis
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Formulation of a bioadhesive bilayered buccal tablet of natamycin for oral candidiasis

机译：用于口服念珠菌病的纳米霉素的生物粘性双层颊皮片的制剂

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摘要

Candidiais induced by Candida albicans is the most common fungal infections of the oral cavity in humans. Topical delivery of antifungal agents within the oral cavity is the most widely accepted approach with techniques aimed at prolonging drug concentrations in the oral cavity. Conventional dosage forms would be the simplest dosage form for the delivery of drugs through the mucosa or to the oral cavity. The main disadvantage of suc dosage forms is an initial burst of activity followed by a rapid decrease in concentrations below therapeutic levels. Oral candida infections require prolonged therapy with antifungal agents. In order to increase the residence time of drugs for local therapy in the oral cavity, several bioadhesive systems have been developed in recent years.
机译：Candida albicans诱导的念珠菌是人类口腔中最常见的真菌感染。口腔内的抗真菌剂的局部递送是最广泛接受的方法，其技术旨在延长口腔中的药物浓度。常规剂型是通过粘膜或口腔递送药物的最简单的剂型。 SuC剂型的主要缺点是初始活性突发，然后在治疗水平以下的浓度快速降低。口服念珠菌感染需要延长治疗抗真菌剂。为了增加药物在口腔中局部治疗的停留时间，近年来已经开发了几种生物粘性系统。

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