Longevity in blood circulation of poly(ethylene glycol) - poly(D,L-Lactide) block copolymer micelles installing charged peptides on the surface.

机译：聚（乙二醇）血液循环中的寿命（乙二醇） - 聚（D，L-丙交酯）嵌段共聚物胶束在表面上安装带电肽。

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Recently, the demand for novel biodegradable polymer as a component of drug carrier to avoid the accumualtion toxicity of the carrier have been increased in the field of drug delivery system. We already reported the preparation and characterization of the micelle formed from block copolymer consisted from poly(ethylene glycol) and biodegradable poly(D,L-lactide) (PEG-PDLLA). Thee micelle have reactive aldehyde groups at the end of PEG (reactive polymeric micelle)~1,2. Then, conjugation of tyrosine (Tyr) and anionic peptidyl ligand (tyrosyl-glutamic acid, Tyr-Glu) was conducted to modulate the surface charge as a model for further improvement in the biofunctionality of biodegradable micellar drug carriers~3.

机译：最近，在药物递送系统领域增加了对药物载体的一种组分作为药物载体的组分的需求，以避免载体的累积毒性。我们已经报道了由聚（乙二醇）和可生物降解的聚（D，L-丙交酯）（PEG-PDLLA）组成的嵌段共聚物形成的胶束的制备和表征。 THEE胶束在PEG（反应性聚合物胶束）末端具有反应性醛基组〜1,2。然后，进行酪氨酸（Tyr）和阴离子肽基配体（酪氨酸 - 谷氨酸，Tyr-Glu）的缀合以调节表面电荷作为模型，以进一步改善生物降解的胶束药物载体的生物功能性〜3。

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《International symposium on controlled release of bioactive materials》|2000年||共2页
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Y.Yamamoto; Y.Nagasaki; Y.Kato; Y.Sugiyama; K.Kataoka;
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中图分类生物材料学;
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1. Lactose-Installed Poly(ethylene glycol)-Poly(D,L-lactide) Block Copolymer Micelles Exhibit Fast-Rate Binding and High Affinity toward a Protein Bed Simulating a Cell Surface. A Surface Plasmon Resonance Study [J] . Eduardo Jule, Yukio Nagasaki, Kazunori Kataoka Bioconjugate Chemistry . 2003,第1期

机译：乳糖安装的聚（乙二醇）-聚（D，L-丙交酯）嵌段共聚物胶束对模拟细胞表面的蛋白质床具有快速结合和高亲和力。表面等离子体共振研究
2. Surface plasmon resonance study on the interaction between lactose-installed poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles and lectins immobilized on a gold surface [J] . Jule E., Nagasaki Y., Kataoka K. Langmuir: The ACS Journal of Surfaces and Colloids . 2002,第26期

机译：乳糖固定的聚乙二醇-聚（D，L-丙交酯）嵌段共聚物胶束与固定在金表面的凝集素之间相互作用的表面等离子体共振研究
3. Sugar-installed polymer micelles: synthesis and micellization of poly(ethylene glycol)-poly(D,L-lactide) block copolymers having sugar groups at the PEG chain end [J] . Yasugi Kenji, Nagasaki Yukio, Kato Masao, Macromolecules . 1999,第24期

机译：装糖的聚合物胶束：在PEG链末端具有糖基的聚（乙二醇）-聚（D，L-丙交酯）嵌段共聚物的合成和胶束化
4. Longevity in blood circulation of poly(ethylene glycol) - poly(D,L-Lactide) block copolymer micelles installing charged peptides on the surface. [C] . Y.Yamamoto, Y.Nagasaki, Y.Kato, International symposium on controlled release of bioactive materials . 2000

机译：聚（乙二醇）血液循环中的寿命（乙二醇） - 聚（D，L-丙交酯）嵌段共聚物胶束在表面上安装带电肽。
5. Poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles for the delivery of drugs with limited aqueous solubility. [D] . Jette, Karen K. 2004

机译：聚（乙二醇）-嵌段-聚（ε-己内酯）胶束，用于输送水溶性受限的药物。
6. Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles [O] . Kouichi Shiraishi, Shin-ichi Yusa, Masanori Ito, 2011

机译：光辐照诱导芯交联的聚（乙二醇）-嵌段-聚（天冬氨酸）胶束：嵌段共聚物的合成优化和芯交联的胶束的表征
7. Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles [O] . Kouichi Shiraishi, Shin-ichi Yusa, Masanori Ito, 2017

机译：照射辐照诱导核心交联聚（乙二醇） - 嵌段 - 聚（天冬氨酸）胶束：嵌段共聚物合成的优化和核心交联胶束的表征

Longevity in blood circulation of poly(ethylene glycol) - poly(D,L-Lactide) block copolymer micelles installing charged peptides on the surface.

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