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Design and synthesis of an amide-linked angiotensin II analogue with 3,5 side chain bridge:structural resemblance of ring cluster conformation with AT_1 non-peptide antagonists

机译：与3,5侧链桥的酰胺连接血管紧张素II类似物的设计与合成：与AT_1非肽拮抗剂的环形簇构象的结构相似

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The novel amide linked Angiotensin II cyclic analogue c-(3,5)-[Sar~1-Lys~3-Glu~5-Ile~8]-ANG II (Figure 1) has been designed,synthesized and bioassayed in anesthetized rabbits.The aim of this work was to investigate furthermore the role of a ring cluster receptor conforation in agonist activity and shed light to intriguing differences in activity and conformation upon replacement of aromatic residue Phe with aliphatic Ile.

机译：新型酰胺连接血管紧张素II环状类似物C-（3,5） - [SAR〜1-LYS〜3-GLU〜5-ILE〜8] - ang II（图1）在麻醉的兔子中合成和生物测量。该工作的目的是进一步研究戒指聚类受体对激动剂活性和脱光的作用，并在用脂族ILe替代芳族残基PHE时对活性和构象的敏化差异。

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《the International Peptide Symposium》|2001年||共2页
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Panagiota Roumelioti; Ludmila Polevaya; Nektarios Giatas; Anastasia Zoga; Ilze Mutule; Tatjana Keivish; Thomas Mavromoustakos; Panagiotis Zoumpoulakis; Demetrios Vlahakos; John Matsuoukas;
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1. Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-Chain bridges. Role of C-Terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists. [J] . Roumelioti P, Polevaya L, Zoumpoulakis P, Bioorganic and Medicinal Chemistry Letters . 2002,第18期

机译：具有3,5侧链桥的环状血管紧张素II类似物的设计，合成和生物学评估。 C末端芳香族残基和环簇对于活性和AT1非肽类拮抗剂药物设计的作用。
2. Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*--pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists. [J] . Polevaya L, Mavromoustakos T, Zoumboulakis P, Bioorganic and medicinal chemistry . 2001,第6期

机译：环状血管紧张素II拮抗剂类似物的合成和研究揭示了pi * -pi *相互作用在C端芳香族残基中的激动剂活性，其结构类似于AT（1）非肽拮抗剂。
3. The design and synthesis of a potent Angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone Angiotensin II. [J] . Matsoukas JM, Polevaya L, Ancans J, Bioorganic and medicinal chemistry . 2000,第1期

机译：有效的血管紧张素II环状类似物的设计和合成证实了血管紧张素II的环簇受体构象。
4. Design and synthesis of an amide-linked angiotensin II analogue with 3,5 side chain bridge:structural resemblance of ring cluster conformation with AT_1 non-peptide antagonists [C] . Panagiota Roumelioti, Ludmila Polevaya, Nektarios Giatas, the International Peptide Symposium . 2001

机译：与3,5侧链桥的酰胺连接血管紧张素II类似物的设计与合成：与AT_1非肽拮抗剂的环形簇构象的结构相似
5. Asymmetric synthesis of stereochemically-defined and conformationally-constrained novel amino acids via direct alkylation of chiral nickel(II)-coordinated Schiff bases of glycine and alanine, and design and synthesis of selective peptide and non-peptide ligands for the delta-opioid receptor. [D] . Tang, Xue-jun. 2002

机译：通过手性镍（II）配位的甘氨酸和丙氨酸的席夫碱直接烷基化的立体化学定义和构象约束的新型氨基酸的不对称合成，以及δ阿片受体的选择性肽和非肽配体的设计和合成。
6. Design Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents [O] . Yong-Tao Duan, Ruo-Jun Man, Dan-Jie Tang, -1

机译：新型链接桥和B环修饰的Combretastatin A-4（CA-4）类似物作为有效的抗微管剂的设计合成和抗肿瘤活性
7. Asymmetric synthesis of stereochemically-defined and conformationally-constrained novel amino acids via direct alkylation of chiral nickel(II)-coordinated Schiff bases of glycine and alanine, and design and synthesis of selective peptide and non-peptide ligands for the delta-opioid receptor [O] . Tang Xue-jun 2002

机译：通过手性镍（II）配位的甘氨酸和丙氨酸的席夫碱直接烷基化的立体化学定义和构象约束的新氨基酸的不对称合成，以及δ-阿片受体的选择性肽和非肽配体的设计与合成

Design and synthesis of an amide-linked angiotensin II analogue with 3,5 side chain bridge:structural resemblance of ring cluster conformation with AT_1 non-peptide antagonists

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