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Incorporation of a cis-amide bond isostere in the synthesis of cyclic tetrapeptides

机译：在合成环肽的合成中掺入CIS-AMIDE键等蹄酮

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Cyclic tetrapeptides are an exciting class of molecules showing a wide range of biological activities.They are very difficult to synthesize due to the inherent strain of the 12 membered ring.Our initial experiments on the inclusion of backbone substituents to increase the propensity for cis conformations of the amide bond resulted in significant improvements in yields for cyclizing these linear precursors.

机译：环状四肽是一种令人兴奋的分子，显示出广泛的生物活性。它们由于12元环的固有菌株而非常难以合成。在包含骨架取代基的初始实验以增加顺式取代基的倾向酰胺键导致用于环化这些线性前体的产率显着改善。

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《the International Peptide Symposium》|2001年||共2页
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Gregory T.Bourne; Peter J.Cassidy; Wim D.F.Meutermans; Marc R.Campitelli; Mark L.Smythe;
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1. Semisynthesis of an Analogue of Antitumor Bicyclic Hexapeptide RA-VII by Fixing the Ala-2/Tyr-3 Bond to Cis by Incorporating a Triazole cis-Amide Bond Surrogate [J] . Yukio Hitotsuyanagi, Shuichi Motegi, Tomoyo Hasuda, Organic letters . 2004,第7期

机译：通过合成三唑顺酰胺键替代物将Ala-2 / Tyr-3键固定为顺式，半合成抗肿瘤双环六肽RA-VII。
2. Semisynthesis of an Analogue of Antitumor Bicyclic Hexapeptide RA-VII by Fixing the Ala-2/Tyr-3 Bond to Cis by Incorporating a Triazole cis-Amide Bond Surrogate [J] . Yukio Hitotsuyanagi, Shuichi Motegi, Tomoyo Hasuda, Organic letters . 2004,第7期

机译：通过合成三唑顺酰胺键替代物将Ala-2 / Tyr-3键固定为顺式，半合成抗肿瘤双环六肽RA-VII。
3. Synthesis and Application of (Z)-Alkene- and (E)-FIuoroaIkene-Dipeptide Isosteres as cis-Amide Equivalents [J] . Kenji Tomita, Tetsuo Narumi, Ayumu Niida Advances in Experimental Medicine and Biology . 2008,第Null期

机译：（Z）-烯烃-和（E）-氟烯烃-二肽等位异构体的合成及应用
4. Incorporation of a cis-amide bond isostere in the synthesis of cyclic tetrapeptides [C] . Gregory T.Bourne, Peter J.Cassidy, Wim D.F.Meutermans, the International Peptide Symposium . 2001

机译：在合成环肽的合成中掺入CIS-AMIDE键等蹄酮
5. Part I. Design and synthesis of bicyclic internal beta-turn mimetics and their incorporation into biologically active ligands; Part II. Synthesis of cyclic peptides by ring closing metathesis. [D] . Min, Byoung Joon. 2010

机译：第一部分：双环内部β-转角模拟物的设计与合成及其掺入生物活性配体中；第二部分通过闭环易位合成环状肽。
6. Formation of Stable DNA Loops by Incorporation of Nonpolar Non-Hydrogen-Bonding Nucleoside Isosteres [O] . Xiao-Feng Ren, Barbara A. Schweitzer, Charles J. Sheils, -1

机译：通过并入非极性非氢键核苷等位基因形成稳定的DNA环。
7. Semisynthesis of an analogue of antitumor bicyclic hexapeptide RA-VII by fixing Ala-2/Tyr-3 bond to cis by incorporating a triazole cis-amide bond surrogate [O] . -1

机译：通过掺入三唑顺式酰胺粘合剂将Ala-2 / Tyr-3键固定Ala-2 / Tyr-3键的抗肿瘤双环己肽Ra-VII的半合成

Incorporation of a cis-amide bond isostere in the synthesis of cyclic tetrapeptides

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