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首页> 外文会议>Mexican Symposium on Medical Physics >Valve Morphology Effect in Aortic Coarctation Flow Using Realistic Silicon Models and Magnetic Resonance Imaging
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Valve Morphology Effect in Aortic Coarctation Flow Using Realistic Silicon Models and Magnetic Resonance Imaging

机译：使用现实硅模型和磁共振成像的主动脉凸起流动阀形态效应

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Aortic valve morphology and phenotype may alter the aortic wall structure and its normal flow hemodynamics. However, the relationship between altered flow patterns and progression of wall pathology is often not fully understood in patients with aortic coartation and needs larger experimental work. In this study, we introduced a compatible experimental setup with magnetic resonance imaging (MRI) using a realistic aortic coarctation (AoCo) silicon model which can replicate physiological flow conditions (pressure, flow-wave, and systemic load). We evaluated the aortic valve hemodynamics of a normal tricuspid valve and a stenotic bicuspid valve using valve effective orifice area (EOA), peak and mean transvalvular pressure gradient (TPG). AoCo severity was assessed by the AoCo pressure gradient. For the tricuspid valve we obtained an EOA = 1.89 cm~2, a peak TPG = 10 mmHg, and a mean TPG = 5 mmHg. For the bicuspid valve we obtained an EOA = 1.03 cm~2, a peak TPG = 37 mmHg and a mean TPG = 13 mmHg. Furthermore, AoCo with tricuspid valve led to a peak AoCo pressure gradient (PG) = 11 mmHg and a mean PG = 5 mmHg. AoCo with bicuspid valve led to a peak PG = 6 mmHg and a mean PG = 3 mmHg. Aortic flow reattachment was more evident in presence of bicuspid valve and helical flow was present in all cases. This study showed that silicon prototyping in combination with MRI velocity measurements could successfully be used to assess hemodynamic effects of aortic valve morphology in aortic coarctation flow.
机译：主动脉瓣形态和表型可以改变主动脉壁结构及其正常流动血流动力学。然而，在主动脉包装的患者中通常没有完全理解改变的流动模式和墙体病理进展之间的关系，并且需要更大的实验工作。在这项研究中，我们使用磁共振成像（MRI）介绍了一种兼容的实验装置，使用现实的主动脉缩窄（AOCO）硅模型可以复制生理流动条件（压力，流浪和全身载荷）。我们评估了正常三尖瓣的主动脉瓣膜血流动力学，使用阀有效孔口区域（EOA），峰值和平均分瓣压力梯度（TPG）进行狭窄的双囊阀。 AOCO压力梯度评估了AOCO严重程度。对于Tricuspid阀，我们获得EOA = 1.89cm〜2，峰TPG = 10mmHg，平均TPG = 5mmHg。对于双裂阀，我们获得了EOA = 1.03cm〜2，峰TPG = 37mmHg和平均TPG = 13mmHg。此外，具有三尖瓣的AOCO导致峰值Aoco压力梯度（PG）= 11mmHg，平均pg = 5mmHg。 AOCO与双囊阀导致峰值PG = 6mmHg，平均pg = 3mmHg。在双裂阀的存在下，主动脉流动重新蚀刻更明显，并且在所有情况下存在螺旋流动。该研究表明，与MRI速度测量结合的硅原型可以成功地用于评估主动脉瓣形态在主动脉凸起流动中的血液动力学效应。

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