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Group-Based Trajectory Analysis for Long-Term Use of Warfarin Therapy in Atrial Fibrillation Patients

机译：基于组的术语轨迹分析，用于高级患者的华法林治疗

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Atrial fibrillation (AF) patients suffer a high risk of ischemic stroke and other thromboembolism (TE). Warfarin is a long-term oral medication and is effective in reducing TE for AF patients. Identifying the trajectory patterns of warfarin use in AF patients and discovering how different trajectories are associated with different TE outcomes are important for understanding long-term use of warfarin. Also, finding the factors affecting future warfarin use and predicting the warfarin use trajectory for new patients can help to efficiently target the specific patient groups and propose relevant interventions for warfarin use. This paper, combining group-based trajectory modeling and predictive modeling, has successfully discovered three patient groups with distinct warfarin use trajectories. Also, results suggest that the warfarin use trajectory has potential association with the TE outcomes. Moreover, results show factors affecting the future trajectory, which have been used to build prediction models for the warfarin use group.

机译：心房颤动（AF）患者患缺血性卒中和其他血栓栓塞（TE）的风险很高。华法林是一种长期口服药物，可有效减少AF患者的TE。鉴定AF患者中的Warfarin的轨迹模式，并发现如何与不同的TE结果相关的不同轨迹对理解Warfarin的长期使用是重要的。此外，寻找影响未来华法林使用和预测新患者的轨迹的因素可以有助于有效地靶向特定患者群体，并提出有关Warfarin使用的相关干预措施。本文结合基于组的轨迹建模和预测建模，已成功发现三个患者组，具有不同的华法林使用轨迹。此外，结果表明，华法林使用轨迹与TE结果具有潜在的关系。此外，结果显示了影响未来轨迹的因素，这些因素已被用于构建华法林使用组的预测模型。

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《MEDINFO》|2017年|xxxvi 679-1403 p.|共5页
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Shijing Guo; Xiang Li; Xin Du; Haifeng Liu; Guotong Xie;
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中图分类医学与其他学科的关系;
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1. Response to Letter Regarding Article, "Efficacy and Safety of Dabigatran Compared With Warfarin in Relation to Baseline Renal Function in Patients With Atrial Fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial Analysis" [J] . Hijazi Ziad, Hohnloser Stefan H., Oldgren Jonas, Circulation: An Official Journal of the American Heart Association . 2014,第22期

机译：对有关“达比加群与华法林相比房颤患者基线肾功能的有效性和安全性的信”的答复：RE-LY（长期抗凝治疗的随机评估）试验分析”
2. Letter by Chin et al Regarding Article, "Efficacy and Safety of Dabigatran Compared With Warfarin in Relation to Baseline Renal Function in Patients With Atrial Fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial Analysis" [J] . Chin Paul K. L., Wright Daniel F. B., Florkowski Christopher M. Circulation: An Official Journal of the American Heart Association . 2014,第22期

机译：Chin等人关于文章的信，“达比加群与华法林相比，房颤患者基线肾功能的功效和安全性：RE-LY（长期抗凝治疗的随机评估）试验分析”
3. Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial analysis. [J] . Ziad Hijazi, Stefan H Hohnloser, Jonas Oldgren, Circulation: An Official Journal of the American Heart Association . 2014,第9期

机译：达比加群与华法林相比在房颤患者基线肾功能方面的疗效和安全性：一项RE-LY（长期抗凝治疗的随机评估）试验分析。
4. Group-Based Trajectory Analysis for Long-Term Use of Warfarin Therapy in Atrial Fibrillation Patients [C] . Shijing Guo, Xiang Li, Xin Du, MEDINFO . 2017

机译：基于组的术语轨迹分析，用于高级患者的华法林治疗
5. Cost effectiveness of warfarin in anticoagulant clinic after introduction of dabigatran for stroke prevention in atrial fibrillation patients in the United States [D] . Alhazami, Mai S. 2015

机译：在美国引入达比加群后预防心房颤动患者中风后华法林在抗凝临床中的成本效益
6. Personalizing the decision of dabigatran versus warfarin in atrial fibrillation: A secondary analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) trial [O] . Samuel W. Reinhardt, Nihar R. Desai, Yuanyuan Tang, 2021

机译：个性化Dabigatran与华法林在心房颤动的决定：长期抗凝治疗的随机评价（RE-LY）试验的二级分析
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Group-Based Trajectory Analysis for Long-Term Use of Warfarin Therapy in Atrial Fibrillation Patients

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