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首页> 外文会议>International Biohydrometallurgy Symposium >Genomic lessons from biomining organisms: case study of the Acidithiobacillus genus
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Genomic lessons from biomining organisms: case study of the Acidithiobacillus genus

机译：生物元化生物的基因组课程：酸酐属植物的案例研究

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Advances in DNA sequencing technologies have promoted the use of genome information as a key component in most of biological studies. In the case of biomining microorganisms, partial and complete genome information has provided critical clues for unraveling their physiology. This information has also provided genetic material for the generation of functional and biodiversity directed markers. In this work, we present a compilation of the most relevant findings based on genomic analysis of the model organism Acidithiobacillus ferrooxidans ATCC23270 that were extended and compared to the recently sequenced genomes of Acithiobacillus thiooxidans and Acidithiobacillus caldus. The phylogenetic relatedness of these three microorganisms has permitted the identification of a shared genomic core that encodes the common metabolic and regulatory functions critical for survival and proliferation in extremely acidic environments. We also identified microorganism-specific genomic components that are predicted to be responsible for the metabolic speciation of these microorganisms. Finally, we evaluated the impact of lateral gene transfer on these genomes in order to determine the functional contribution of this phenomenon to the fitness of these microbial representatives. The information gathered by genomic analyses in the Acidithiobacillus genus will be presented in conjunction with other biomining genomic and metagenomic information in order to generate a more comprehensive picture of the biodiversity, metabolism and ecophysiology of the bioleaching niche.
机译：DNA测序技术的进展促进了大多数生物学研究中的基因组信息作为关键组分。在生物化微生物的情况下，部分和完整的基因组信息已经提供了解除其生理学的关键线索。该信息还提供了用于产生功能和生物多样性定向标记的遗传物质。在这项工作中，我们提出了基于延伸的模型生物体酸酐酸酐的基因组分析的最相关结果的汇编，其延伸，与Acithiobacillus硫代苯胺和酸酐的最近测序的基因组延伸。这三种微生物的系统发育相关性允许鉴定共同的基因组核心，该基因组核心编码在极其酸性环境中对存活和增殖至关重要的常见代谢和调节功能。我们还确定了预测这些微生物的代谢物种负责的微生物特异性基因组组分。最后，我们评估了横向基因转移对这些基因组的影响，以确定这种现象对这些微生物代表的适应性的功能贡献。基因组分析在酸酐中收集的信息将与其他生物元素基因组和偏见信息一起呈现，以便为生物多样性的生物多样性，新陈代谢和生态学的生物多样性的更全面的图像进行呈现。

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