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首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Effects of pulsatile versus nonpulsatile flow on cerebral hemodynamics during pediatric cardiopulmonary by pass with deep hypothermic circulatory arrest
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Effects of pulsatile versus nonpulsatile flow on cerebral hemodynamics during pediatric cardiopulmonary by pass with deep hypothermic circulatory arrest

机译：脉腭与非乳化流动对脑血流动力学在儿科心动动脉血管循环循环循环骤停血期间的影响

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Cardiopulmonary bypass (CPB) with total circulatory arrest (TCA) adversely affects the neurologic outcome of pediatric patients after cardiac surgery. This study is designed to determine the effects of pulsatile versus nonpulsatile perfusion on regional and global cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO{sub}2), cerebral oxygen delivery (CDO{sub}2), and cerebral vascular resistance (CVR) before and after TCA in a neonatal piglet model. Twelve piglets were used in pulsatile (n = 6) and nonpulsatile (n = 6) groups. All piglets underwent 60 minutes of TCA and 45 minutes of rewarming. CBF, CMRO{sub}2, CDO{sub}2, and CVR were determined before TCA at a cerebral perfusion pressure (CPP) of 55 mmHg, and after TCA at CPP's of 55, 40, and 70 mmHg. Pulsatile flow increased regional and global CBF, CMRO{sub}2, and CDO{sub}2, and decreased CVR compared to nonpulsatile perfusion at all experimental stages. However, CBF, CMRO{sub}2, CDO{sub}2, and CVR diminished after TCA in both groups. These results suggest that the use of pulsatile flow improves cerebral recovery after TCA, and thus it may minimize brain injury compared to nonpulsatile flow in neonates and infants. Our results also confirm that TCA is the major cause for cerebral dysfunction during CPB.
机译：具有总循环停止（TCA）的心肺旁路（CPB）对心脏手术后小儿患者的神经系统结果产生不利影响。本研究旨在确定脉腭与非乳液灌注对区域和全局脑血流量（CBF）的影响，氧化氧代谢率（CMRO {Sub} 2），脑氧递送（CDO {} 2）和脑在新生小猪模型中TCA之前和之后的血管抗性（CVR）。在脉腭（n = 6）和非乳液（n = 6）基团中使用12个仔猪。所有仔猪都经过60分钟的TCA和45分钟的复员。 CBF，CMRO {Sub} 2，CDO {Sub} 2和CVR在TCA之前在55mmHg的脑灌注压力（CPP），TCA为55,40和70mmHg之后。与所有实验阶段的非分娩灌注相比，脉动流量增加了区域和全球CBF，CMO {Sub} 2和CDO {Sub} 2，并降低了CVR。然而，在两个组中TCA后，CBF，CMO {Sub} 2，CDO {Sub} 2和CVR减少。这些结果表明，与新生儿和婴儿的非分娩流程相比，使用脉动流动的使用改善了脑恢复，因此可以使脑损伤最小化。我们的结果还证实，TCA是CPB期间脑功能障碍的主要原因。

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