首页> 外文会议>Annual International Conference of the IEEE Engineering in Medicine and Biology Society >Evaluation of a recoil-escape fiber target using 94{sup left}Mo(p,n)(94m){sup left}Tc to produce 94{sup left}TcO{sub}4{sup}- precursor for radiolabeled compounds useful in positron emission tomography
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Evaluation of a recoil-escape fiber target using 94{sup left}Mo(p,n)(94m){sup left}Tc to produce 94{sup left}TcO{sub}4{sup}- precursor for radiolabeled compounds useful in positron emission tomography

机译:使用94 {sup left} mo(p,n)(94m)(94m){sup left} tc来评估recoil-rese纤维靶标以产生94 {sup left} tco {sub} 4 {sup} - 用于放射性标记化合物的前体用于可用的正电子发射断层扫描

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A variety of compounds radiolabeled with (99m){sup left}Tc(140 keV γ T{sub}(1/2)=6 hours) are widely used in nuclear medicine imaging. These compounds can also be radiolabeled using positron-emitting precursor (94m){sup left}TcO{sub}4{sup}-(T{sub}(1/2) = 53 minutes) and used with Positron Emission Tomography (PET) to measure tissue concentrations in μCi/cm{sup}3, and produce kinetic data useful to understand the mechanism of drug action. This work-in-progress evaluates a novel accelerator target for producing (94m){sup left}Tc. Positron emitters have been produced with fiber targets, using the principle of recoil escape in which the target atoms are in a solid form, while recovering the product radionuclide ion by stopping it in a liquid or a gas. The recoil ion is transported out of the target, leaving the remaining target material to be used repeatedly in subsequent production runs. Our proposed target is based on this method.
机译:用(99m){sup左} Tc(140keVγt{sub}(1/2)= 6小时)放射性标记的各种化合物被广泛用于核医学成像。这些化合物也可以使用正电子发射前体(94m){sup left} tco {sub} 4 {sup} - (t {sub}(1/2)= 53分钟)放射性标记,并与正电子发射断层扫描(PET)一起使用为了测量μCI/ cm {sup} 3的组织浓度,并产生有用的动力学数据,可用于了解药物作用的机制。该过程评估了一种新型加速器靶标的(94米){SUP左} TC。使用纤维靶制成正电子发射器,使用反冲叶片原理,其中靶原子以固体形式,同时通过在液体或气体中停止产物放射性核离子离子。反冲离子输出靶,将剩余的靶材料留在随后的生产运行中。我们所提出的目标是基于这种方法。

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