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Photo-induced acoustic spectra of biological tissues and photoacoustic tomography by phase-controlled focus algorithm

机译:通过相控制的聚焦算法,光学组织和光声断层扫描的光学诱导的声学光谱

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Photoacoustic tomography has attracted high attention in recent years, because this imaging technique can combine the advantages of ultrasound and light to improve the image resolution and diagnostic depth of tissues. In this paper, spectroscopic feature of photo-induced acoustic signal generated in biological tissues are investigated, and its characteristics are analyzed in time domain and in frequency domain. The results show that spectrum of photoacoustic signal changes with the property of tissue sensitively. A spectrum-selective photoacoustic imaging might be a potential approach to diagnose special disease at the early stage. According to the spectral characteristics of photoacoustic signal, here, we present a photoacoustic tomography of real tissue to depth of ~12mm by selecting a wide-band high-sensitive detector. The time-resolved technique and a phase-controlled focus algorithm was used for image reconstruction, and a depth resolution up to ~10 μm and a lateral resolution about 300 μ were obtained.
机译:近年来,光声断层扫描引起了高度关注,因为这种成像技术可以将超声波和光的优点结合起来改善图像分辨率和诊断组织的诊断深度。本文研究了生物组织中产生的光诱导声学信号的光谱特征,并在时域和频域中分析其特征。结果表明,光声信号的光谱敏感地随组织的性质而变化。光谱选择性光声成像可能是在早期诊断特殊疾病的潜在方法。根据光声信号的光谱特性,这里,我们通过选择宽带高敏感探测器,将真实组织的光声断层扫描到〜12mm的深度。将时间分辨技术和相控焦算法用于图像重建,获得高达约10μm的深度分辨率和约300μm的横向分辨率。

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