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Effects of low dose-rate irradiation on the glucose metabolism in type II diabetes model mice

机译：低剂量率辐射对II型糖尿病模型小鼠葡萄糖代谢的影响

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We examined the effects of low dose-rate irradiation on the levels of glucose and insulin in the mice. Ten-week-old female type II diabetes model (db) mice were irradiated with -y-rays at 0.30, 0.70 or 1.2 mGy/h. The level of plasma glucose and the level of plasma insulin was measured. After the irradiation for 24 days, in the control mice, the level of insulin was decreased to 50% of the initial level, while the decrease was significantly less in the irradiated mice. The mice were irradiated for 2 weeks, and then, after one night fast, they were subjected to a glucose tolerance test. In the irradiated mice, the glucose level was gradually increased. In the non-irradiated mice, the glucose level increased rapidly and the level was kept. These results suggest that the low dose-rate irradiation improved the effectiveness of insulin on the insulin metabolisms and the glucose metabolism in the db mice.
机译：我们研究了低剂量率照射对小鼠葡萄糖和胰岛素水平的影响。用0.30,0.70或1.2 mgs / h的-y射线照射十周龄女性II型糖尿病模型（DB）小鼠。测量血浆葡萄糖水平和血浆胰岛素水平。在辐照后24天后，在对照小鼠中，胰岛素的水平降低至初始水平的50％，而辐照小鼠的降低显着较低。将小鼠辐照2周，然后在快速一夜之后，对它们进行葡萄糖耐量试验。在辐照小鼠中，葡萄糖水平逐渐增加。在非照射小鼠中，葡萄糖水平迅速增加，并且保持水平。这些结果表明，低剂量率辐照改善了胰岛素对胰岛素代谢的有效性以及DB小鼠中的葡萄糖代谢。

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