Heavy ion induced transformation of telomerase immortalized human small airway epithelial cells

机译：重离离子诱导端粒酶转化永生化人类小气道上皮细胞

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The tumorigenic effects of galactic cosmic rays (GCR) have become a major concern to the members of the international space station program. Normal human small airway epithelial cells were immortalized by ectopic expression of hTERT. The hTERT-expressing cells were exposed to ~(56)Fe ions which simulate GCR irradiation. The irradiated cells underwent a stepwise transformation process. They showed phenotypic alterations and loss of some chromosomes compared with control hTERT-expressing cells.

机译：银河系宇宙射线（GCR）的致瘤效应已成为国际空间站计划成员的主要关注点。通过HTETT的异位表达，使正常人体小气道上皮细胞永生化。将表达的细胞暴露于模拟GCR辐射的〜（56）Fe离子。辐照细胞接受逐步转化过程。与表达HTETT的细胞相比，它们显示出表型改变和一些染色体的丧失。

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来源
《International Conference on High Levels of Natural Radiation and Radon Areas》|2005年|1st ed|共3页
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作者
Chang Q. Piao; Yong L. Zhao; M. Suzuki; A. Balajee; Tom K. He;
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原文格式 PDF
正文语种
中图分类放射卫生;
关键词
Transformation; Heavy ions; Telomerase; hTER;

机译：转化;重离子;端粒酶;传中;

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1. Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. [J] . Zhuang ZH, Tsao SW, Deng W, Journal of gastroenterology and hepatology . 2008,第10期

机译：人乳头瘤病毒16型中环氧合酶2的早期上调和端粒酶诱导的人食管上皮细胞永生。
2. One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation [J] . Jordan L. Smith, Liam C. Lee, Abigail Read, Cell & Bioscience . 2016,第1期

机译：可一步致癌的人气道上皮细胞一步一步永生化
3. p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase. [J] . Shao G, Balajee AS, Hei TK, Molecular Carcinogenesis . 2008,第10期

机译：p16INK4a的下调与端粒酶诱导的人前列腺原代上皮细胞永生化有关。
4. Heavy ion induced transformation of telomerase immortalized human small airway epithelial cells [C] . Chang Q. Piao, Yong L. Zhao, M. Suzuki, International Conference on High Levels of Natural Radiation and Radon Areas . 2005

机译：重离离子诱导端粒酶转化永生化人类小气道上皮细胞
5. Adenovirus E1A 12S-induced changes during immortalization and transformation of primary epithelial cells. [D] . Gopalakrishnan, Shobha. 1996

机译：腺病毒E1A 12S诱导的原代上皮细胞永生化和转化过程中的变化。
6. One-step immortalization of primary human airway epithelial cells capable of oncogenic transformation [O] . Jordan L. Smith, Liam C. Lee, Abigail Read, 2016

机译：一步一步永生化原代人气道上皮细胞能够致癌性转化
7. Immortalization of Human Small Airway Epithelial Cells by Ectopic Expression of Telomerase [O] . Chang Q. Piao, Li Liu, Yong L. Zhao, 2005

机译：端粒酶异位表达对人小气道上皮细胞的永生化作用
8. Do Telomerase Inhibitors Prevent the Spontaneous Immortalization of Breast Epithelial Cells from Individuals Predisposed to Breast Cancer [R] . Herbert, B. , Shay, J. W. 2002

机译：端粒酶抑制剂预防乳腺癌易感个体乳腺上皮细胞的自发永生化

Heavy ion induced transformation of telomerase immortalized human small airway epithelial cells

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