Modulation of CD95 (APO-1/Fas)-induced hepatocyte death by NO

机译：CD95（APO-1 / Fas）的调节 - 诱导肝细胞死亡

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During recent years, a significant body of evidence has accumulated supporting the role of apoptosis and, particularly, of the CD95 death receptor-ligand system in liver disease. Many non-lymphoid tissues, such as the liver, constitutively express CD95 and are thus sensitive to activation by CD95L. The cell-surface receptor CD95 (APO-1/Fas) is a major trigger of apoptosis and cells rapidly undergo apoptotic cell death upon CD95 stimulation via GD95L or agonistic antibodies. The importance of the CD95 system in liver pathophysiology and homeostasis is well documented. We have described in different forms of acute and chronic liver failure, including viral infections, alcoholic liver damage, Wilson's disease and others, that deregulation of the CD95 receptor and/or lig-and is causally involved in disease progression. Lymphocytes as well as liver cells themselves have been identified as pathogenetic relevant sources of CD95L in liver disease. Further support for an important role of CD95 in the liver comes from studies using animal models in which it has been demonstrated that interruption of CD95/CD95L interaction prevents liver damage.

机译：近年来，一系列重要的证据积累了肝脏疾病中CD95死亡受体 - 配体系统的作用。许多非淋巴组织，例如肝脏，组成思考CD95，因此对CD95L的活化敏感。细胞表面受体CD95（apo-1 / Fas）是细胞凋亡和细胞的主要触发，并且通过GD95L或激动抗体在CD95刺激时迅速进行凋亡细胞死亡。 CD95系统在肝脏病理生理学和稳态中的重要性有很好的记录。我们已经以不同形式的急性和慢性肝衰竭描述，包括病毒感染，酒精性肝脏损伤，威尔逊疾病和其他疾病，对CD95受体和/或LIG的放松管制症，并导致疾病进展。淋巴细胞以及肝细胞本身已被鉴定为肝病中CD95L的致病相关来源。进一步支持CD95在肝脏中的重要作用来自使用动物模型的研究，其中已经证明CD95 / CD95L相互作用的中断可防止肝损伤。

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《International Symposium on the Maillard Reaction》|2002年||共6页
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P. R. GALLE; D. STRAND; Z. SU; M. THEOBALD; C. C. HARRIS; S. STRAND;
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1. Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression. [J] . Kaser A, Nagata S, Tilg H Cytokine . 1999,第10期

机译：干扰素α通过上调Fas（CD95 / APO-1）和Fas配体表达来增加激活诱导的T细胞死亡。
2. Cell Death Inhibiting RNA (CDIR) modulates IFN-gamma-stimulated sensitization to Fas/CD95/Apo-1 and TRAIL/Apo-2L-induced apoptosis. [J] . Shchors K, Yehiely F, Deiss LP Cell cycle . 2004,第12期

机译：细胞死亡抑制RNA（CDIR）调节IFN-γ刺激的Fas / CD95 / Apo-1和TRAIL / Apo-2L诱导的细胞凋亡的敏感性。
3. Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signaling complex. [J] . Scaffidi C, Krammer PH, Peter ME Methods: A Companion to Methods in Enzymology . 1999,第4期

机译：CD95（APO-1 / Fas）死亡诱导信号复合物成分的分离和分析。
4. Modulation of CD95 (APO-1/Fas)-induced hepatocyte death by NO [C] . P. R. GALLE, D. STRAND, Z. SU, International Symposium on the Maillard Reaction . 2002

机译：CD95（APO-1 / Fas）的调节 - 诱导肝细胞死亡
5. Roles of cellular FLICE-inhibitory protein (c-FLIP) and PI3K/Akt in Fas (CD95)-induced NF-kappaB activation and apoptosis through death effector domains. [D] . Lu, Bin. 2005

机译：细胞FLICE抑制蛋白（c-FLIP）和PI3K / Akt在Fas（CD95）诱导的NF-κB活化和细胞凋亡中通过死亡效应域的作用。
6. T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)- mediated apoptosis of CD4+ T cells from human immunodeficiency virus- infected persons [O] . 1995

机译：T辅助1 / T辅助2细胞因子和T细胞死亡：白细胞介素12对活化诱导的和CD95（FAS / APO-1）介导的人免疫缺陷病毒感染者CD4 + T细胞凋亡的预防作用
7. Cell Death Inhibiting RNA (CDIR) Modulates IFN-gamma;-Stimulated Sensitization to Fas/CD95/Apo-1 and TRAIL/Apo-2L-Induced Apoptosis [O] . Ksenya Shchors, Fruma Yehiely, Louis P. Deiss 2004

机译：细胞死亡抑制RNA（CDIR）调节IFN-γ刺激的敏化对Fas / CD95 / APO-1和TRAIL / APO-2L诱导的细胞凋亡

Modulation of CD95 (APO-1/Fas)-induced hepatocyte death by NO

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