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Development of in vivo high resolution individual based neuroanatomical atlases using magnetic resonance imaging

机译：使用磁共振成像在体内高分辨率中基于基于神经杀菌的神经杀死中的发展

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The study of individual variation in brain anatomy has been neglected by most researchers in the functional brain imaging field. Almost all results of functional imaging experiments are referenced to standard atlases or "average" anatomical features. We believe that individual variation will inform us of crucial structural, developmental and functional aspects of the human brain, particularly with the rapidly expanding knowledge of the human genome. As a first step towards this we describe a non-invasive method of generating high resolution unique anatomical atlases for each subject in an experimental group using magnetic resonance imaging (MRI). Essentially, the method enables images of partial brain regions from multiple imaging sessions to be progressively combined into a high resolution neuroanatomical atlas. In this way, a single high resolution brain volume can be built up like "patchwork" from separate partial brain volumes. This will allow precise localisation and correlation of functional results and we believe will be hypothesis-generating in the areas of developmental, neurobiology and clinical neuroscience.
机译：在功能性脑成像领域的大多数研究人员中，对脑解剖学的个体变异的研究已经忽略了。几乎所有功能成像实验的结果都参考标准的地图集或“平均”解剖学特征。我们认为，个人变异将向我们通知我们人脑的关键结构，发育和功能方面，特别是随着人类基因组的快速扩大知识。作为朝向这一步的第一步，我们描述了使用磁共振成像（MRI）在实验组中为每个受试者产生高分辨率独特解剖结构的非侵入性方法。本质上，该方法使得从多个成像会话中的部分脑区的图像能够逐渐组合成高分辨率的神经杀死atlas。以这种方式，可以从单独的部分脑体积中建立单个高分辨率脑体积。这将允许精确定位和功能结果的相关性，并且我们认为将在发育，神经生物学和临床神经科学领域产生假设。

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