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首页> 外文会议>Society of Photo-Optical Instrumentation Engineers Conference on Ophthalmic Technologies >Using Optical Coherence Tomography to Evaluate Glaucoma Implant Healing Response in Rabbit Eyes
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Using Optical Coherence Tomography to Evaluate Glaucoma Implant Healing Response in Rabbit Eyes

机译：使用光学相干断层扫描来评估兔眼的青光眼植入愈合反应

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摘要

Glaucoma is a set of diseases that cause optic nerve damage and visual field loss. The most important risk factor for the development of glaucoma is elevated intraocular pressure. One approach used to alleviate the pressure increase is to surgically install glaucoma implants. Two standard Ahmed and ten experimental ePTFE implants were evaluated in this study in rabbit eyes. The implants were images with optical coherence tomography (OCT) at 0, 7, 15, 30, and 90 days after implantation. Histology was collected at days 7, 15, 30, and 90 and compared to the OCT images. Preliminary analysis of images indicates that OCT can visualize the development of fibrous encapsulation of the implant, tissue erosion, fibrin accumulation in the implant tube, and tube position in the anterior chamber. A new OCT handheld probe was developed to facilitate in vivo imaging in rabbit eye studies. The OCT probe consists of a mechanical scaffold designed to allow the imaging fiber to be held in a fixed position with respect to the rabbit eye, with minimal anesthesia. A piezo electric lateral scanning device allows the imaging fiber to be scanned across the tissue so that 2-D images may be acquired.
机译：青光眼是一组导致视神经损伤和视野损失的一系列疾病。青光眼发展最重要的风险因素是眼压升高的升高。用于缓解压力增加的一种方法是手术上安装青光眼植入物。在兔眼中，在这项研究中评估了两种标准AHMED和10个实验EPTFE植入物。植入物是在植入后0,7,15,30和90天的光相干断层扫描（OCT）的图像。在第7,15,30和90天收集组织学并与OCT图像相比。图像初步分析表明，OCT可以可视化植入物，组织侵蚀，纤维蛋白积聚在植入管中的纤维包封的发展，以及前房中的管位置。开发了一种新的OCT手持探针，以促进兔眼研究中的体内成像。 OCT探针包括用于允许成像纤维相对于兔眼保持在固定位置的机械支架上，具有最小的麻醉。压电横向扫描装置允许成像光纤扫描组织，使得可以获得2-D图像。

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