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首页> 外文会议>International Symposium on Blood Transfusion >QUANTITATIVE REAL-TIME PCR FOR DETECTION OF PARVOVIRUS B19 DNA IN BLOOD PLASMA FOR PLASMA SCREENING.
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QUANTITATIVE REAL-TIME PCR FOR DETECTION OF PARVOVIRUS B19 DNA IN BLOOD PLASMA FOR PLASMA SCREENING.

机译：用于检测血浆血浆中Parvovirus B19 DNA的定量实时PCR。

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摘要

Human Parvovirus B19 (PV-B19) is a 18-26 nm small, non-enveloped, single stranded DNA virus belonging to the family Parvoviridae. The virus has a tro-pism for red blood cell progenitors. Most of the clinical manifestations due to viral infection are related to impairment of the functions of red blood cell progenitors (i.e. transient aplastic crisis, pure red cell aplasia) or to circulating immune complexes resulting from infection (Erythema infectiosum, rash, arthropa-thy). PV-B19 is normally transmitted via the respiratory route. PV-B19 is commonly found in blood donors. The prevalence of high viremic PV-B19 infection among blood donors is estimated between 1:20,000 to 1:50,000 [1]. However, during micro epidemic periods the prevalence can be as high as 1:260 [1]. The high viremic period after infection is usually short and very intense with PV-B19 loads up to 10~14 copies /ml in plasma. After this initial burst of virus, infected individuals stay low viremic for a prolonged period up to several months with load <10~4 copies/ml in plasma. Although normally transmitted via the respiratory route, parental transmission of PV-B19 can occur via the administration of blood components and blood derivatives. Transmission via blood components originating from a single donor occurs only rarely. The reported cases include a recipient of an infected red cell unit with thalassemia [2] and recipients who underwent bone marrow [3] or liver transplantation. These rare observations are in contrast with many reports on the transmission of PV-B19 via blood derivatives such as clotting factor concentrates, albumin and IVIG [4].
机译：人parvovirus b19（pv-b19）是属于parvoviridae的家庭的18-26nm的小，不包裹的单链DNA病毒。病毒对红细胞祖细胞具有一个特性。由于病毒感染引起的大多数临床表现与红细胞祖细胞血管血管血管血管血管血管血管血管血管血管血管血管血管血管血管血管血管毒剂（即纯红细胞ALASIA）或循环免疫复合物的损害有关（红斑传染病，皮疹，节肢动术） 。 PV-B19通常通过呼吸道透过。 PV-B19通常在献血者中发现。献血者中高病毒性PV-B19感染的患病率估计在1：20,000至1：50,000之间[1]之间。然而，在微观流行期间，患病率可以高达1：260 [1]。感染后的高毛动死时期通常短而非常强烈，PV-B19载量高达10〜14份/ mL。在这种初始爆发病毒后，受感染的个体在血浆中长达几个月的时间保持低毛发病，血浆中的载荷<10〜4拷贝/ ml。尽管通常通过呼吸道途径传播，但是PV-B19的父母透射可以通过血液成分和血液衍生物进行。通过来自单个供体的血液成分的传输很少发生。报告的病例包括具有炎症的红细胞单元的受体，其血症[2]和接受骨髓[3]或肝移植的接受者。这些罕见的观察结果与许多关于通过血液衍生物（如凝血因子浓缩物），白蛋白和IVIG的血液衍生物传递的报告相反。

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