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首页> 外文会议>Annual Meeting of the American Association of Swine Veterinarians >Efficacy of a single intramuscular dose of ceftiofur hydrochloride (Excenel~(R) RTU) at 5mg ceftiofur equivalents/kg body weight for the treatment of naturally occurring bacterial swine respiratory disease
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Efficacy of a single intramuscular dose of ceftiofur hydrochloride (Excenel~(R) RTU) at 5mg ceftiofur equivalents/kg body weight for the treatment of naturally occurring bacterial swine respiratory disease

机译：盐酸头孢噻呋喃的肌肉内剂量（ExceneL〜（r）的疗效在5mg头孢噻呋呋喃/ kg体重治疗天然存在的细菌猪呼吸道疾病中的疗效

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Weaned pigs (N=2601) at nine locations in the United States were removed from antibiotics (feed, water and parenteral) for 14 days. After at least 14 days of antibiotic removal, pigs (N=346, 9 locations; BW 3.6kg to 24.5kg) exhibiting clinical signs of swine respiratory disease (SRD) were enrolled on study on day 0 when they scored 2 or greater for a combined respiratory index (4 category index) and general appearance (5 category index) and also had a body temperature >104° F. Enrolled pigs were randomly assigned to receive one intramuscular injection of either ceftiofur hydrochloride (Excenel~(R) RTU) at 5.0mg ceftiofur equivalent (CE) per kg BW or placebo (sterile water) at the same dose volume (0.1 ml/kg BW). Clinical observations were performedon study pigs for 7 days and body temperatures were taken on days 1, 3 and 6 following treatment on day 0. Necropsies were performed and lung lesions scored on 3 sentinel pigs at each location, on all pigs that died during the study and all surviving pigs, which were sacrificed on day 14 post-enrollment. Microbiological identification of bacterial organisms was performed on the lungs of all enrolled pigs. The study required a minimum of eight locations enrolling at least 23 pigs/location for appropriate statistical power. The data from one site were excluded from statistical analyses because assays of the feed samples indicated that chlorretracycline (93.5g/ton) and oxytetracycline (226.4g/ton) were present in the pre-enrollment feed. Analysis of thedata for pigs (N=303) at the remaining eight locations indicated that pig mortality wassignificantly (P=0.04) lower for the ceftiofur hydrochloride (HC1) treated pigs (2.1%) than for the Placebo pigs (8.0%). Clinical cure rate was defined as the percentage of pigs that had a combined general appearance score and respiratory score of either0 or 1 and a body temperature of less than 104 F on both days 3 and 6 post-enrollment. The clinical cure rate for ceftiofur HC1 treated pigs (7.1 %) was not significantly better (P=0.36) than that of placebo treated pigs (8.0%). Lung lesion scores of ceftiofur HC1 treated pigs (13.3%) were not significantly less (P=0.34) than the scores of pigs receiving placebo (11.0%). Likewise, the percentage of ceftiofur HC1 pigs that gained 2.5 kg in the 14-day post-enrollment period (81.9%) was not significantlygreater (P=0.46) than the percentage of placebo treated pigs (83.5%) that gained 2.5% kg. Body temperatures of ceftiofur HC1 treated pigs (104.0°F day 1, 104.0°F day 3) were significantly (P<0.006) lower than body temperatures of placebo treated pigs (104.5°F day 1, 104.4°F day 3) on days 1 and 3 post-treatment.
机译：在美国的九个地区的断奶猪（n = 2601）从抗生素（饲料，水和肠胃外）中除去14天。在至少14天的抗生素去除后，猪（n = 346,9个位置; bw 3.6kg至24.5kg）在第0天开始研究猪呼吸道疾病（srd）的临床症状，当他们得分2或更大结合呼吸指数（4类指数）和一般外观（5类指数），并且还有体温> 104°F。随机分配猪猪猪，以接受一个盐酸头孢噻呋喃（Excenel〜（R）RTU）肌内注射一次每kg BW或安慰剂（无菌水）在相同剂量（0.1ml / kg bw）中的5.0mg头孢噻呋喃（Ce）。临床观察是在第0天治疗后的第1天，3和6天的研究猪7天的研究猪，在0时进行治疗。在每个地点的每个位置的3个哨兵猪中进行，肺病变在研究期间死亡所有存活的猪，在入学后第14天处死。对所有注册猪的肺部进行细菌生物的微生物鉴定。该研究要求至少八个地点注册至少23个猪/位置，以适当的统计功率。来自一个部位的数据被排除在统计学分析之外，因为进料样品的测定表明，在招生前饲料中存在氯酰碳碱（93.5g /吨）和催产素（226.4g /吨）。留下八个位置的猪（n = 303）的TheData分析表明，对于盐酸头孢噻呋盐（HC1）处理的猪（2.1％）比安慰剂猪（8.0％）降低猪死亡率（p = 0.04）。临床固化率被定义为猪的猪百分比，其在入学后3和6天在3和6天的ANY0或1的呼吸评分和体温小于104°F。头孢噻呋喃HC1处理猪（7.1％）的临床固化率没有明显更好（p = 0.36），而不是安慰剂处理的猪（8.0％）。头孢噻呋喃HC1处理猪的肺病灶分数（13.3％）不显着较低（p = 0.34），而不是接受安慰剂的猪（11.0％）。同样，在入学后期的14天（81.9％）中获得2.5千克的头孢菌HC1猪的百分比并不明显（p = 0.46），而不是降低治疗猪的百分比（83.5％）2.5％kg。头孢噻呋喃HC1处理猪的身体温度（104.0°F天，104.0°F第3天）显着（p <0.006）低于安慰剂处理猪的身体温度（104.5°F第1天，104.4°F第3天）在几天内1和3后治疗。

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