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A Bayesian approach to the analysis of cDNA microarray data

机译:CDNA微阵列数据分析的贝叶斯方法

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The recent explosion of interest in microarray technology has resulted in it becoming the preferred methodology for conducting gene expression experiments. Although the ability of an array experiment to simultaneously examine the expression of thousands of genes gives a previously unheard of level of insight to researchers, it also raises a plethora of statistical questions involving both the sheer volume of data being produced, as well as the variability inherent in this technology. In this paper we present statistical methods based on Bayesian linear models to investigate the various sources of variability present in array experiments. Data from a previously published cDNA microarray experiment is used to illustrate this methodology.
机译:最近对微阵列技术的爆炸导致它成为进行基因表达实验的优选方法。虽然阵列实验同时检查成千上万基因表达的能力给出了先前闻所未闻的研究人员的洞察水平,但它也提出了一种涉及所产生的数据的纯粹数量的统计问题,以及可变性这种技术固有。在本文中,我们提出了基于贝叶斯线性模型的统计方法来研究阵列实验中存在的各种可变性来源。来自先前公布的cDNA微阵列实验的数据用于说明该方法。

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