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首页> 外文会议>Annual Rocky Mountain Bioengineering Symposium >COMPARISON OF TAIL-SUSPENSION AND SCIATIC NERVE CRUSH ON THE MUSCULOSKELETAL SYSTEM IN YOUNG-ADULT MICE
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COMPARISON OF TAIL-SUSPENSION AND SCIATIC NERVE CRUSH ON THE MUSCULOSKELETAL SYSTEM IN YOUNG-ADULT MICE

机译：尾悬架和坐骨神经压迫对年轻成人小鼠肌肉骨骼系统的比较

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Musculoskeleta unloading and disuse result in significant muscle and bone loss. These phenomena can be modeled using sciatic nerve crash or tail-suspension, Mature animals eliminate the complication of growth superimposed on bone and muscle loss. In the current study, young-adult (12-week old male) C57BL/6J mice were subjected to sciatic nerve crush (NC; n=9) or tail-suspension (TS; n=9) for 14 days, with a normal ambulatory control (n=10). The soleus, gastrocnemius, and EDL muscles were collected and weighed at sacrifice. Femurs were analyzed in three-point bending for stiffness, elastic force and maximum force. Muscle masses in tail suspended mice were reduced by 41.9% (p＜0.001), 17.5% (p＜0.001), and 9.1% (N.S.) for the soleus, gastrocnemius, and EDL, respectively. In NC mice, muscle masses were reduced by 18.6% (p=0.004), 37.2% (p＜0.001), and 22.5% (p=0.003), Femur stiffness, elastic and maximum forces were reduced by 20.9% (p=0.014), 14.7% (N.S.), and 11.6% (N.S.) in TS, compared to NC where masses were reduced by 15.5% (p=0.022), 0.2% (N.S.) and 11.2% (N.S.) in the crushed leg compared to the contralateral control. NC resulted in a greater reduction of muscle mass in the gastrocnemius and EDL muscle; whereas tail-suspension had a greater effect on the soleus. Tail-suspension had the greatest effect on bone mechanical properties. When comparing these results to actual spaceflight data, it appears as though TS most closely models muscle loss, and NC most closely models changes in bone mechanical properties. These unloading models have tissue-specific effects that impact their applications for musculoskeletal research.
机译：肌肉骨骼卸载和消毒导致显着的肌肉和骨质损失。这些现象可以使用坐骨神经崩溃或尾悬浮液进行建模，成熟的动物消除叠加在骨骼和肌肉损失上的生长的并发症。在目前的研究中，幼年（12周龄雄性）C57BL / 6J小鼠对坐骨神经粉碎（NC; n = 9）或尾悬浮（TS; n = 9）进行14天，正常动态控制（n = 10）。 Contin，Soleus，Gastrocnemius和EDL肌肉被收集并在牺牲中称重。在三点弯曲中分析股骨以进行刚度，弹力力和最大力。尾悬浮小鼠的肌肉质量分别减少41.9％（P <0.001），17.5％（P <0.001）和9.1％（P <0.001）和9.1％（N，N，N，N，N.），酶，胃肠杆菌和EDL。在NC小鼠中，肌肉质量减少18.6％（P = 0.004），37.2％（P <0.001），22.5％（P = 0.003），股骨刚度，弹性和最大力减少20.9％（P = 0.014与NC相比，TS的14.7％（ns）和11.6％（ns），其中质量减少15.5％（p = 0.022），与碎腿中的0.2％（ns）和11.2％（ns）相比对侧控制。 NC导致腓肠肌和EDL肌肉中的肌肉肿块更加减少;尾悬浮液对单独的效果更大。尾悬架对骨骼机械性能产生了最大的影响。在将这些结果与实际的空间数据进行比较时，它看起来似乎最关心的肌肉损失，NC最突出的模型骨骼机械性能变化。这些卸载模型具有影响其对肌肉骨骼研究的应用的组织特异性效果。

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