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首页> 外文会议>International Congress on Coronary Artery Disease >Effect of Minimal Extracorporal Circulation (MECC) Compared to Cardiopulmonary Bypass System(CPB) on Organ Function and Inflammatory Response A Prospective Randomized Study
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Effect of Minimal Extracorporal Circulation (MECC) Compared to Cardiopulmonary Bypass System(CPB) on Organ Function and Inflammatory Response A Prospective Randomized Study

机译：促进体外循环（MECC）与心肺旁路系统（CPB）对器官功能和炎症反应的影响效果A前瞻性随机研究

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The use of minimized extracorporeal systems (MECC) is gaining clinical acceptance in coronary bypass grafting, because of the reduced inflammatory response that is responsible for organ dysfunctions and neurological disorders. Low priming volume influences the hemostasis and is associated with reduced blood product use. Aim of this study was the investigation of effects on organ function and neurological dysfunction. In a prospective, randomized study 90 patients underwent an elective coronary artery bypass grafting using either mini-extracorporeal circulation (MECC-group n=90) or conventional cardiopulmonary bypass (CPB-group, n=45) since March 2004. Reoperations and concomitant valve procedures were excluded. The mean age was 66+-9years in the CPB- group and 65+-8 years in the MECC- group. Blood levels of cytokines (IL6, IL 8, IL10, TNF alpha), complement fac-tors( C3,C4), myocardial markers (creatinkinase, Troponin T), S100B, haemoglobin and thrombocytes were serially measured at different time points (preoperatively, 0,1,6,12,24,48 hours after CPB).
机译：利用最小化的体外系统（MECC）在冠状动脉旁路接枝中获得临床验收，因为对器官功能障碍和神经系统障碍负责的炎症反应降低。低灌注体积影响止血，与降低的血液产品使用相关。本研究的目的是对器官功能和神经功能障碍的影响调查。在预期的，随机研究以来，90例患者接受了专注于2004年3月以来使用迷你循环（MECC-GROUP N = 90）或常规心肺旁路（CPB-GROUP，N = 45）的选修冠状动脉旁路接枝。重新进一步和伴随阀程序被排除在外。 CPB集团的平均年龄为66 + -9岁，在MECC-GROUP中为65 + -8岁。细胞因子（IL6，IL 8，IL10，TNFα），互补因子（C3，C4），心肌标记物（Creatonalin氨基酶，肌钙蛋白T），S100b，血红蛋白和血小板细胞的细胞水平在不同的时间点串联测量（术前， CPB后0,1,6,12,24,4,48小时）。

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