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首页> 外文会议>Hirosaki International Forum of Medical Science >Effect of delayed treatment with basic fibroblast growth factor on the survival of striatal spiny projection neurons after perinatal hypoxia-ischemia
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Effect of delayed treatment with basic fibroblast growth factor on the survival of striatal spiny projection neurons after perinatal hypoxia-ischemia

机译：基本成纤维细胞生长因子延迟治疗对围产量缺氧缺血后纹状体多穴突出神经元存活的影响

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Recent studies suggest that delayed treatment with growth factors, including basic fibroblast growth factor (bFGF), may protect against neuronal death after brain injury. This delayed protective effect is particularly relevant to hypoxic-ischemic brain injury during the third trimester of pregnancy, since detection of the insult is much more likely once the fetus is born. The effect of delayed growth factor treatment has only been partly characterized, however, after perinatal hypoxic-ischemic injury. This injury is thought to be a major cause of motor disorders (e.g. cerebral palsy) and mental retardation in children. In both humans and rats, one of the damaged brain regions after perinatal hypoxia-ischemia is the striatum. We therefore determined the effect of delayed treatment with basic fibroblast growth factor at 24 and 48 h after perinatal hypoxia-ischemia on nerve cell survival within the rat striatum. The total number of surviving striatal spiny projection neurons was measured using modern stereological methods. It was found that delayed treatment with basic fibroblast growth factor did not improve the total number of surviving spiny projection neurons within the rat striatum after perinatal hypoxia-ischemia. Additional studies investigating the possibility of more subtle protective effects on surviving neurons by this treatment paradigm are warranted. ?2003 Elsevier Science B.V. All rights reserved.
机译：最近的研究表明，延迟治疗生长因子，包括碱性成纤维细胞生长因子（BFGF），可能在脑损伤后免受神经元死亡。这种延迟的保护作用与怀孕三个三个月期间的缺氧缺血性脑损伤特别相关，因为一旦胎儿出生，侵蚀的检测得多。然而，在围产期缺氧缺血性损伤之后，延迟生长因子治疗的影响仅部分是部分特征。这种伤害被认为是运动障碍的主要原因（例如脑瘫）和儿童精神发育迟滞。在人类和大鼠中，围产期缺氧缺血后受损的大脑区域之一是纹状体。因此，我们确定在大鼠纹状体内神经细胞存活后24和48小时在24和48小时的碱性成纤维细胞生长因子延迟治疗的效果。使用现代立体方法测量存活的纹状体刺孔凸起神经元的总数。发现患有碱性成纤维细胞生长因子的延迟治疗没有改善围产量缺氧缺血后大鼠纹状体内存活的多刺突出神经元的总数。额外研究调查该治疗范式对存活神经元更细微的保护作用的可能性。 ？2003年elestvier science b.v.保留所有权利。

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