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首页> 外文会议>Hirosaki International Forum of Medical Science >Hypertrophy of the medial globus pallidus in 6-hydroxydopamine-lesioned rats treated with levodopa
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Hypertrophy of the medial globus pallidus in 6-hydroxydopamine-lesioned rats treated with levodopa

机译：用左旋多巴处理的6-羟基戊胺 - 损伤大鼠中间地球肺炎的肥大

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The motor effects of levodopa, evidenced by rotation behavior, became enhanced upon intermittent administration in rats with unilateral lesions of the nigrostriatal dopamine pathway by 6-hydroxydopamine (6-OHDA). However, the mechanisms of this behavioral sensitization, which is regarded to be analogous to levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD), remain unknown. The fact that pallidotomy dramatically improves LIDs indicates that the medial globus pallidus (MGP) plays an important role in the development of LIDs. We found hypertrophy of the MGP in 6-OHDA-lesioned rats treated with levodopa twice daily for 2 weeks. The rats showed marked behavioral sensitization to levodopa. Furthermore, coadministration of 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) with levodopa attenuated this hypertrophy together with prevention of the sensitization. These results suggest that this hypertrophy is an essential pathological change in the rodent model of LIDs. ?2003 Elsevier Science B.V. All rights reserved.
机译：通过旋转行为证明的左旋多巴的电机效应在纽格多巴胺（6-OHDA）的单侧病变的大鼠中间歇施用时变得增强。然而，这种行为致敏的机制被认为是类似于帕金森病（PD）患者的左司豚鼠诱导的止咳虫（盖子），仍然未知。缺点术语显着改善盖子的事实表明，中间球蛋白（MGP）在盖子的发展中起重要作用。我们发现在每天两次用左旋多巴处理的6-OHDA损伤大鼠中MGP的肥大2周。大鼠显示对左旋多巴的有明显的行为敏化。此外，用Levodopa的8-羟基-2（Di-N-丙基氨基）四rallin（8-OH-DPAT）的共同分析与预防敏化一起减弱这种肥大。这些结果表明，这种肥大是盖子啮齿动物模型的基本病理变化。 ？2003年elestvier science b.v.保留所有权利。

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