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首页> 外文会议>Asian Pacific Society of Respirology >Comparision of Oral Levofloxacin and Ceftriaxone plus Clarithromycin in the Treatment of Hospitalized Patients with Lower Respiratory Tract Infections
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Comparision of Oral Levofloxacin and Ceftriaxone plus Clarithromycin in the Treatment of Hospitalized Patients with Lower Respiratory Tract Infections

机译：口服左氧氟沙星和头孢曲松加上克拉霉素治疗住院治疗患者患者患者患者

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Levofloxacin, a Z-form of fluoroquinolone ofloxacin, has demonstrated a broad range of activity against Gram-positive and Gram-negative organisms and anaerobes. Oral and intravenous levofloxacin are 99% bioequivalent and have excellent tissue penetration (1). Recent randomized trials have indicated that 7 to 14 days treatment with levofloxacin was as effective as those commonly used comparator agents in patients with community-acquired pneumonia. Overall clinical response rates were 86 to 95% (2). Kahn and his colleagues recently reported that sequential (intravenous +- oral switch) therapy with levofloxacin 500mg once daily was at least as effective as sequential regimen for the same duration with ceftriaxone plus erythromycin followed by amoxicillin/clavulanic acid plus clarithryomycin in the treatment of severe CAP. Again, a multicenter, open-label, randomized study has shown the similar results in hospitalized patients with moderate to severe CAP receiving levofloxacin monotherapy in comparing to a combination regimen of azithromycin and ceftriaxone in providing coverage against the current causative pathogens in CAP (3). This study is to assess the efficacy, length of stay and medical costs of oral levofloxacin in comparison with ceftriaxone plus clarithromycin in the treatment of hospitalized patients with lower respiratory tract infections.
机译：Levofloxacin，氟甲磺酰胺氟喹啉的Z形式，已经表现出抗革兰氏阳性和革兰氏阴性生物和厌氧的广泛活性。口服和静脉内左氧氟沙星为99％生物等效，具有优异的组织渗透（1）。最近的随机试验表明，用左氧氟沙星治疗7至14天，与社区肺炎患者常用的比较剂一样有效。整体临床反应率为86至95％（2）。 Kahn和他的同事们最近报道了与左氧氟沙星的顺序（静脉+口腔开关）治疗每日一次，每天至少有效地用Ceftriaxone加红霉素与持续的持续时间有效，然后是阿莫西林/克拉维酸加上克拉霉素治疗严重帽。再次，多中心，开放标签随机研究表明，与阿奇霉素和头孢曲松的组合方案相比，接受左旋氧氟沙星单疗法的住院治疗患者的患者的相似结果与盖帽（3）中的目前致病病原体的覆盖率相比。本研究是评估口服左氧氟沙星的疗效，住院时间和医疗成本与Ceftriaxone Plus Clarithromycin治疗患有呼吸道感染的住院患者。

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