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Bioethics and Innovation in Pediatric Nutrition Research

机译:儿科营养研究的生物伦理和创新

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Advances in technology and understanding of fundamental human biology allow for an increasingly innovative research agenda in pediatric nutrition. All human research is governed by the norms of bioethics, which are in turn based on four primary principles: free will in participation, freedom from harm, opportunity to benefit, and non-discrimination in access. Legally, if not essentially, juveniles do not have free will to affirm their participation as research subjects. They have an absolute right, in nontherapeutic research, however, to decline. Pivotal in the discussion in nonthera-peutic research in healthy children is the tolerance for risky procedures. Complicated situations include: multi-national protocols, choice of developing country sites, the inclusion of placebo treatment arms, analysis of genetic biomarkers, and research for commercial enterprises. The overly stringent interpretation of bioethical principles, as adapted to children, would stifle innovation in research. A relaxed bioethical attitude in pursuit of advancing science, by contrast, could violate essential human rights and expose a population worthy of special protection to undue risk and harm. By following the course of utility, seeking the steepest benefit-to-risk ratios, weighted toward safety and child welfare, the divergent nature of the considerations should be brought into convergence for the sake of continuing innovation.
机译:技术与对基本人体生物学的概况允许对儿科营养的日益创新的研究议程。所有人类研究都受到生物伦理的规范,即基于四个主要原则:自由将参与,自由免受伤害,机会的自由,获取的机会和非歧视。合法的,如果不是基本上,少年没有自由意志肯定他们作为研究科目的参与。然而,它们具有绝对的权利,然而,在非洲化研究中,拒绝。在健康儿童的非实验研究中讨论的关键是风险程序的宽容。复杂的情况包括:多国议定书,开发国家场地的选择,包括安慰剂治疗武器,遗传生物标志物分析,以及商业企业的研究。适应儿童的生物道原则的过度严格的解释将扼杀研究的创新。相比之下,追求推进科学的轻松生物态度可能违反了基本的人权,并使人口公开了不必要的风险和危害的特殊保护。通过遵循效用,寻求最陡峭的益处风险比率,加权安全和儿童福利,应促进持续创新的考虑因素的不同性质。

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