The role and utility of intraoperative radiation therapy (IORT) are still a matter of value judgement for treatment of malignant brain tumors. We report our 10-year experience with 67 patients (26 grade WHO III brain tumors, 41 glioblastomas grade WHO IV)., who have been involved for IORT. After tumor resection using computer-navigation system and histopathological checking of tumor-brain borderline zone navigation-system aided IORT with a dose of 15 to 25 Gy (9 to 18 MeV) was delivered. No increase of perioperative complications or other sequelae were observed. On the basis of our results with prolongation of the median specific survival time to 15,3 months in grade WHO III tumors and to 12,1 months in glioblastoma the IORT can be postulated as a worthwhile additional therapy option in the treatment of malignant brain tumors.
展开▼
