Gene Expression Profiling of Human Gliomas

机译：人胶质瘤的基因表达谱

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The development of optimal treatment strategies adapted to individual patients, and identification of novel molecular targets for therapy require further insights into molecular aspects of glioblastoma development. Gene expression profiles of over 50 astroeytic gliomas provided evidence for inherent differences between tumor classes. Subsequent identification of correlated genes best differentiating between primary glioblastoma, low grade astrocytoma, and respective secondary glioblastoma revealed biological features implicating differences in the behavior of the tumors. In particular angiogenic activity is as a strong predictor of subtypes as indicated by a separating gene cluster characterized by angiogenic factors. A gene expression based tumor classifier was built and tested successfully on an independent set of astrocytic glioma.

机译：适应各个患者的最佳治疗策略的发展，以及鉴定治疗的新型分子靶标需要进一步了解胶质母细胞瘤发育的分子方面。 50多种雌激素胶质瘤的基因表达谱提供了肿瘤课程的固有差异的证据。随后鉴定初级胶质母细胞瘤，低级星形细胞瘤和各次生胶质母细胞瘤之间的相关基因最佳分化，揭示了肿瘤行为差异的生物学特征。特别地，血管生成活性是亚型的强预测因子，如分离基因簇所示，其特征在于血管生成因子。基于基于基因的肿瘤分类器在独立的星形胶质细胞胶质瘤上成功进行了建立和测试。

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《European Congress of Neurosurgery》|2003年||共4页
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ME. Hegi; S. Godard; G. Getz; M. Delorenzi; P. Farmer;
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中图分类头部及神经外科学;
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1. Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. [J] . Li A, Walling J, Kotliarov Y, Molecular cancer research: MCR . 2008,第1期

机译：基因组变化和基因表达谱显示，已建立的神经胶质瘤细胞系不能很好地代表原代人神经胶质瘤。
2. Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets. [J] . Fuller GN, Hess KR, Rhee CH, Brain pathology . 2002,第1期

机译：人类弥漫性神经胶质瘤的分子分类通过基因表达谱的多维缩放分析与基于形态学的分类相平行，与存活率相关，并揭示了与临床相关的新型神经胶质瘤子集。
3. Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. [J] . Guo Y, Liu S, Wang P, Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2011,第4期

机译：胚胎干细胞相关基因Oct4，Sox2和Nanog在人脑胶质瘤中的表达谱。
4. Gene Expression Profiling of Human Gliomas [C] . ME. Hegi, S. Godard, G. Getz, European Congress of Neurosurgery . 2003

机译：人胶质瘤的基因表达谱
5. Gene expression profiling of chemoresistance in human malignant gliomas. [D] . Rhiew, Richard B. 2004

机译：人类恶性神经胶质瘤中化学抗性的基因表达谱。
6. Integrated analysis of genome-wide DNA methylation gene expression and protein expression profiles in molecular subtypes of WHO II-IV gliomas [O] . Zhi-Liang Wang, Chuan-Bao Zhang, Jin-Quan Cai, 2015

机译：综合分析WHO II-IV胶质瘤分子亚型的全基因组DNA甲基化基因表达和蛋白质表达谱
7. Genomic Changes and Gene Expression Profiles Reveal That Established Glioma Cell Lines Are Poorly Representative of Primary Human Gliomas [O] . Aiguo Li, Jennifer Walling, Yuri Kotliarov, 2008

机译：基因组变化和基因表达谱揭示了成立的胶质瘤细胞系代表原发性胶质瘤的代表差

Gene Expression Profiling of Human Gliomas

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