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Elevated C-Reactive Protein and Maintenance of Atrial Fibrillation

机译:升高的C反应蛋白和心房颤动的维持

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We determined the effect of inflammation on progression of atrial fibrillation (AF). Methods: Sterile pericarditis was created in 12 dogs. Before and 2 days after operation, the C-reactive protein (CRP) level, duration of induced AF5 atrial effective refractory period (AERP) of the right atrial appendage, and intra-atrial conduction time were determined. Results: On the 2nd postoperative day, sustained AF (> 200 sec, mean; 540+-351 sec) was induced in 7 dogs (group A), and non-sustained AF (< 200 sec, mean; 82+-84 sec) was induced in 5 dogs (group B). Group A had a higher CRP (11.8+-1.3 vs. 7.2+-0.6 mg/dL, p<0.001), a shorter AERP (122+-4 vs. 139+-13 ms, p<0.05), and a longer intra-atrial conduction time (56+-7 vs. 46+-5 ms, p<0.05) than group B. Conclusion: In this model, elevated CRP was associated with sustained AF, suggesting that electrophysiological changes resulting from inflammation perpetuate AF.
机译:我们确定了炎症对心房颤动进展的影响(AF)。方法:在12只狗中产生无菌心包炎。在操作之前和2天后,确定C反应蛋白(CRP)水平,诱导的AF5心房有效耐火剂时期(AERP)的右心房阑尾和内耳内传导时间。结果:在7只狗(A组)和非持续的AF(<200秒)中诱导持续的AF(> 200秒,平均值; 540 + -351秒)诱发AF(> 200秒,平均值; 540 + -351秒)。 )在5只狗(B组)中诱发。 A组具有较高的CRP(11.8 + -1.3节,7.2 + -0.6mg / dl,p <0.001),较短的AERP(122 + -4与139 + -13ms,P <0.05),更长心房内传导时间(56 + -7与46 + -5ms,P <0.05)。结论:在该模型中,升高的CRP与持续的AF相关,表明炎症永久性的电生理学变化延续。

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