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Treatment of FVIIl-Autoantibodies by Protein I-based Immunoadsorption and Immunosuppression: I iegimen without FVIII Substitution

机译：蛋白质I基免疫吸附和免疫抑制治疗FVIIL - 自身抗体：I Iegimen没有FVIII替代

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There are two main goals in the treatment of acquired FVIII-inhibitors: first, to control acute bleeding episodes and second, to induce immune tolerance (IT). For the induction of IT mainly immunosuppressive drugs are given (e.g. cortico-steroids, cyclophosphamide). As part of the ?Malmo treatment protocol? (MTP) and its modifications they are combined with immunoadsorptions (IA), intravenous immunoglobulins (IVIG) and the causative antigen, i.e. FVIII. The application of FVIII in huge doses for immune modulation is associated with very high costs and therefore there is still an important question: Is a FVIII substitution really mandatory?

机译：在获得的FVIII抑制剂的治疗中有两个主要目标：首先，控制急性出血发作和第二，诱导免疫耐受性（IT）。为了诱导它主要是给出免疫抑制药物（例如皮质类固醇，环磷酰胺）。作为Malmo治疗方案的一部分？（MTP）及其修饰它们与免疫载体（IA），静脉内免疫球蛋白（IVIG）和致病性抗原组合，即FVIII。 FVIII在大量的免疫调节剂量中的应用与较高的成本相关，因此仍然存在一个重要问题：是FVIII替代真正强制性吗？

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《Hemophilie-Symposion》|2003年||共7页
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U. Geisen; R. Grossmann; B.-Mansouri-Taleghani; CM. Schambeck; M. Bock; U. Walter;
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中图分类出血性疾病;
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1. ABO-mismatch adult living donor liver transplantation using antigen-specific immunoadsorption and quadruple immunosuppression without splenectomy. [J] . Troisi R, Noens L, Montalti R, Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society . 2006,第9期

机译：ABO不匹配成人活体供体肝移植，使用抗原特异性免疫吸附和四重免疫抑制，无需脾切除术。
2. Treatment of severe autoimmune blistering skin diseases with combination of protein A immunoadsorption and rituximab: A protocol without initial high dose or pulse steroid medication [J] . KolesnikM., BeckerE., ReinholdD., Journal of the European Academy of Dermatology and Venereology: JEADV . 2014,第6期

机译：结合蛋白A免疫吸附和利妥昔单抗治疗严重的自身免疫性水疱性皮肤疾病：无需初始高剂量或脉搏类固醇药物治疗的方案
3. Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution (vol 111, 53, 2016) [J] . Ameling Sabine, Bhardwaj Gourav, Hammer Elke, Basic Research in Cardiology: Official Journal of the German Association of Cardiovascular Research . 2017,第4期

机译：用随后免疫球蛋白替代（Vol 111,53,2016）的免疫吸附后扩张心肌病患者心肌基因表达和蛋白质组合物的变化（Vol 111,2016）
4. Treatment of FVIIl-Autoantibodies by Protein I-based Immunoadsorption and Immunosuppression: I iegimen without FVIII Substitution [C] . U. Geisen, R. Grossmann, B.-Mansouri-Taleghani, Hemophilie-Symposion . 2003

机译：蛋白质I基免疫吸附和免疫抑制治疗FVIIL - 自身抗体：I Iegimen没有FVIII替代
5. Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution [O] . Sabine Ameling, Gourav Bhardwaj, Elke Hammer, -1

机译：免疫吸附后免疫球蛋白替代后扩张型心肌病患者心肌基因表达和蛋白组成的变化
6. ABO-mismatch adult living donor liver transplantation using antigen-specific immunoadsorption and quadruple immunosuppression without splenectomy [O] . Troisi Roberto, Noens Lucien, Montalti Roberto, 2006

机译：aBO错配成人活体肝移植使用抗原特异性免疫吸附和四重免疫抑制无脾切除术

Treatment of FVIIl-Autoantibodies by Protein I-based Immunoadsorption and Immunosuppression: I iegimen without FVIII Substitution

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