首页> 外文会议>Annual Meeting of the National Mastitis Council >Study of the Humoral Immunological Response After Vaccination With a Staphylococcus aureus Biofilm-Embedded Bacterin in Dairy Cows: Possible Role of the Exopolysaccharide Specific Antibody Production
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Study of the Humoral Immunological Response After Vaccination With a Staphylococcus aureus Biofilm-Embedded Bacterin in Dairy Cows: Possible Role of the Exopolysaccharide Specific Antibody Production

机译:乳制奶牛葡萄球菌葡萄球菌染色菌疫苗接种后的体液免疫反应研究:外偶糖特异性抗体生产的可能作用

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The objective of the present study was to analyze an extracellular component from Staphylococcus aureus (S. aureus), which we refer to as Slime Associated Antigenic Complex (SAAC), and to investigate the role of SAAC-specific antibody production in protection from S. aureus bovine mastitis. Data on the specific role of biofilm matrix polysaccharides in the development of a protective immune response against S. aureus mastitis are limited. Recently, Perez et al. (2009) found that bacterins from strongbiofilm-producing bacteria triggered the highest production of antibodies to PNAG and conferred the highest protection against infection and mastitis in an immunization-challenge study in sheep, compared with weak biofilm-producing bacteria, crude extract or purified PNAG. It was concluded that bacterins from strong biofilm bacteria, rather than purified polysaccharide, could be a cost-efficient vaccination approach against S. aureus mminant mastitis. Here, we used two bacterin preparations, with different SAAC content, to perform an immunization-challenge study against S. aureus mastitis in cows.
机译:本研究的目的是分析来自金黄色葡萄球菌(金黄色葡萄球菌)的细胞外组分,我们将其称为粘液相关抗原复合物(SAAC),并研究SAAC特异性抗体生产在S的作用。金黄色葡萄球菌牛乳腺炎。关于生物膜基质多糖在对S.UUREUS乳腺炎的保护性免疫应答发展中的特定作用的数据有限。最近,Perez等人。 (2009)发现,来自强肥化菌的细菌的菌株引发了Pnag抗体的最高产量,并赋予绵羊弱生物膜产生的免疫攻击性研究中的免疫攻击性研究中的最高保护和乳腺炎。粗提取物或纯化的Pnag相比。得出结论,来自强生物膜细菌的菌丝,而不是纯化的多糖,可能是针对金黄色葡萄球菌茂物炎的成本有效的疫苗接种方法。在这里,我们使用了两个细菌制剂,其具有不同的SAAC含量,以对奶牛中的金黄色葡萄球菌乳腺炎进行免疫攻击性研究。

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